crystal sage Posted January 14, 2007 #1 Share Posted January 14, 2007 http://www.theage.com.au/news/Business/Pep...6335660056.html http://www.calflora.net/bloomingplants/pettyspurge.html " Peplin's skin cancer gel trial a success * * Email * Print * Normal font * Large font May 1, 2006 - 4:09PM AdvertisementAdvertisement Early clinical trials of a new gel to treat skin cancer have returned promising results. The gel, developed by Brisbane-based company Peplin, can be rubbed on to the skin to treat certain types of skin cancer. Initial trials show just two applications of the PEP005 Topical gel on two consecutive days cleared up 71 per cent of basal cell carcinomas, or BCCs, the most common type of skin cancer. The trials on 60 people throughout Australia built on an early study by Peplin in 2002 using the common garden weed, petty spurge. "That was a very different study and that was just using the raw sap of petty spurge," said Michael Aldridge, Peplin's managing director and chief executive. "This is the same company and we have now identified the molecule responsible for that activity and we have put that into a formal development program, formulated a gel and developed a manufacturing technology. "We ran a phase one study in the US, two phase-two studies looking at sunspots, and this is our third phase-two study looking at basal cell carcinomas." Mr Aldridge said it was the first time the molecule from petty spurge had been used to treat BCCs, which are usually surgically removed." http://www.theage.com.au/news/Business/Ski...8796701526.html Link to comment Share on other sites More sharing options...
frogfish Posted January 14, 2007 #2 Share Posted January 14, 2007 Acute kerato-uveitis associated with topical self-administration of the sap of the Petty Spurge (Euphorbia peplus) http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_docsum I see nothing about Petty Spurge fighting skin carcinomas in PubMed Link to comment Share on other sites More sharing options...
crystal sage Posted January 14, 2007 Author #3 Share Posted January 14, 2007 http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_docsum I see nothing about Petty Spurge fighting skin carcinomas in PubMed Is that your bible??? Maybe they haven't updated it yet??? http://www.rirdc.gov.au/comp02/eoi1.html " * species in medicine and survey their potential for agricultural cultivation. Background: Recent research by a small Brisbane-based, Australian-owned company Peplin Biotech Ltd in conjunction with the Queensland Institute of Medical Research has found that extracts from milkweed (Euphorbia peplus) and potentially other Euphorbia species (e.g. E.esula, E.lathyris, E.terracina and E.lagascae) have significant anti-cancer activity in mice and humans. Euphorbia is a large genus of some 2000 species with milky sap, often with poisonous or medicinal uses. It includes beneficial as well as weedy plants, of which some 45 species are found in Australia. Although milkweed and the other promising Euphorbia spp. are new to agriculture, environmental requirements for their cultivation have been established in the course of earlier research by Peplin Biotech and QIMR. The active compounds are unable to be synthesised on a commercial scale and have been patented by Peplin Biotech. An early version of the product has given >90% complete responses on skin cancers in a Phase II clinical trial." "Peplin Biotech has discovered a novel class of natural compounds, purified from Euphorbia, which show great potential in the laboratory as a potent treatment for a wide range of human cancers including breast, prostate cancer and skin cancers. An early clinical trial on thick and thin non-melanoma skin cancers has confirmed that the compounds are very effective in producing long-term (possibly permanent) responses in human patients without any evident systemic toxicity when applied topically. E.peplus is one of a number of plants in the Euphorbiaceae family that has attracted attention as a home remedy for skin cancer because of its milky sap. However, a survey by Peplin Biotech of over 200 species of the Euphorbiaceae family has shown that only E.peplus has the desired attributes of anti-cancer efficacy. In addition, E.peplus is not a noxious weed, it grows rapidly, produces harvestable seed and it is potentially suitable for large-scale agricultural production. Methods have been developed by Peplin Biotech for the extraction and purification of compounds from E.peplus in the laboratory, and these are currently being scaled-up for commercial production. It is anticipated that the overall cost of producing the active ingredient in pure form will result in a commercially viable treatment, provided the cost of agricultural production can be kept low. Currently, the plant is sown and harvested by hand and tended in small plots. The limiting factor in capturing commercial value from these discoveries is therefore the availability of plant feedstock for the extraction of active compounds. Developing large-scale agricultural production can solve this problem. " http://www.desert-tropicals.com/Plants/Eup.../Euphorbia.html Link to comment Share on other sites More sharing options...
frogfish Posted January 15, 2007 #4 Share Posted January 15, 2007 PubMed is a standard for publications of research papers worldwide. It is a database consisting of thousands of journals. To see not one paper it quite convincing that "Peplin" hasn't published their findings. Link to comment Share on other sites More sharing options...
crystal sage Posted January 15, 2007 Author #5 Share Posted January 15, 2007 PubMed is a standard for publications of research papers worldwide. It is a database consisting of thousands of journals. To see not one paper it quite convincing that "Peplin" hasn't published their findings. So does that invalidate the findings??? Who owns ...runs..PubMed??? Who controls what is published???? Link to comment Share on other sites More sharing options...
frogfish Posted January 15, 2007 #6 Share Posted January 15, 2007 The NCBI runs PubMed PubMed, like I said, is a collection of thousands of scientific journals worldwide. Peplin must publish their findings, which they haven't. Link to comment Share on other sites More sharing options...
crystal sage Posted January 15, 2007 Author #7 Share Posted January 15, 2007 Wouldn't this qualify??? http://www.qimr.edu.au/news/2004/index.html "Scientific peers validate PEP005 research 15 April 2004 The Queensland Institute of Medical Research (QIMR) and Peplin Biotech Ltd. have announced that five years of collaborative research on Peplin's new cancer drug, PEP005, has been published in the prestigious peer reviewed international journal, Cancer Research (Cancer Res. 2004 Apr 15;64(8):2833-9). This joint project involved QIMR scientists Steve Ogbourne and Peter Parsons (Melanoma Genomics) and Andreas Suhrbier (Immunovirology) and other members of their laboratories. Peplin Executive Director of Research, Dr Jim Aylward said publication of the research paper in such a highly respected journal was an enormous validation by international peers of the quality of the science behind PEP005. "While we are moving forward aggressively to commercialise PEP005 for skin cancer with our US partner Allergan, it is gratifying to receive such respected recognition," said Dr Aylward, who is a co-author of the paper. "It is also instructive to appreciate the wide range of other cancers that this molecule may be effective in treating." The article illustrates that three daily topical applications of PEP005 onto the skin above the tumour resulted in complete clearance of tumours in mice. These tumours include melanoma and squamous cell carcinoma (both skin cancers) and lung, cervical and prostate cancers. Importantly, after a few weeks the skin over the previously existing tumour is almost normal, without significant scarring or loss of flexibility. The article also highlighted that PEP005 as a topical agent has a new cancer killing mechanism, which is different from the way that current cancer chemotherapy kills cancer cells. PEP005 induces primary necrotic cell death rather than the apoptotic cell death that is caused by current chemotherapeutic agents. QIMR Director, Professor Michael Good said the article was testimony to Queensland's world class research climate. "QIMR has been intimately involved in the development of Queensland intellectual property. It is rewarding to see the quality of Queensland research affirmed by our international peers, and also to see it move forward towards commercial reality," he said. Minister for State Development and Innovation Mr. Tony McGrady said the article demonstrated that the Queensland Government's significant investment in biotechnology was paying off." Link to comment Share on other sites More sharing options...
The Skeptic Eric Raven Posted January 15, 2007 #8 Share Posted January 15, 2007 So does that invalidate the findings??? Yes. We need established guidelines for study of meds or compounds. Otherwise, people can claim any effect they want to. Thats whats wrong with supplement companies now. They are able to claim effects with no studies to back them up. Link to comment Share on other sites More sharing options...
crystal sage Posted January 15, 2007 Author #9 Share Posted January 15, 2007 (edited) Yes. We need established guidelines for study of meds or compounds. Otherwise, people can claim any effect they want to. Thats whats wrong with supplement companies now. They are able to claim effects with no studies to back them up. For most of the world's history...we only had natural products to heal us.... Those studies/researches are hugely expensive...and only huge pharmacuetical companies seem to be able to afford them.... maybe there should be a voluntary feedback with these more natural treatments.... where the purchaser/users of these can fill in questionaires about their experiences with these remedies at the stores or online.... with maybe, if possible, the doctor's comments/data included... It makes sense... What bothers me is how they make medicines ...vitamins... chemically?? ... using what , recycled refuse?????? I don't see any huge organic farms etc that provide those companies with the raw ingredients for their end product... I read somewhere once that there are only 4 major sources/companies that supply all the ingrediants for the medications of the world... Is that true???? Edited January 15, 2007 by crystal sage Link to comment Share on other sites More sharing options...
frogfish Posted January 16, 2007 #10 Share Posted January 16, 2007 I read somewhere once that there are only 4 major sources/companies that supply all the ingrediants for the medications of the world... Not true... Link to comment Share on other sites More sharing options...
crystal sage Posted January 16, 2007 Author #11 Share Posted January 16, 2007 (edited) Not true... Are Lab made... sythetic vitamins as healthy as the real thing??? ..because instinct says it can't be.... (says a Berocca fan.. probably all fake) http://www.globaldrugsdirect.com/berocca/l...ideeffects.aspx http://www.theglobeandmail.com/series/vill...ories/6feb.html http://www.mcvitamins.com/synthetic-vitamins.htm http://www.hpakids.org/holistic-health/art...tic-vs.-Natural http://www.admani.com/allianceequine/TechB..._BioPotency.htm eg... " since the establishment of these values, there have been additional studies conducted to determine the biopotency of vitamin E compounds. The relative biopotency of dl-alpha and d-alpha tocopheryl acetates covers a wide range of values according to species, stage of production, degree of tissue depletion, dietary concentration, and measured response. The reported values have ranged from 1.2 to 3 times greater biopotency for d-alpha-tocopheryl acetate (natural vitamin E source) compared to dl-alpha-tocopheryl acetate (synthetic vitamin E source). Based on uptake and retention, body tissue data indicates a preference for d-alpha-tocopherol. The data in Table 3 shows the difference in relative concentration and retention of vitamin E in body tissues when comparing the natural (d) and synthetic (dl) forms. Metabolic differences have been shown in a human study. Volunteers consuming 150 mg of deuterium-labeled d-alpha or dl-alpha excreted 2.7 times more dl-alpha than d-alpha. This demonstrated a preference to more rapidly metabolize and excrete the dl-alpha form. Based on recent animal studies, d-alpha-tocopheryl acetate (natural) may be a better alternative to increase tissue levels and retention of vitamin E compared to dl-alpha-tocopheryl acetate (synthetic)." Edited January 16, 2007 by crystal sage Link to comment Share on other sites More sharing options...
The Skeptic Eric Raven Posted January 16, 2007 #12 Share Posted January 16, 2007 For most of the world's history...we only had natural products to heal us.... Those studies/researches are hugely expensive...and only huge pharmacuetical companies seem to be able to afford them.... maybe there should be a voluntary feedback with these more natural treatments.... where the purchaser/users of these can fill in questionaires about their experiences with these remedies at the stores or online.... with maybe, if possible, the doctor's comments/data included... Ever heard of the placebo effect. Using just feedback is worthless. I know you are anti medicine, but I bet if your child was dying of cancer you would take him or her to a doctor not a shaman(or I hope you would). Link to comment Share on other sites More sharing options...
eqgumby Posted January 16, 2007 #13 Share Posted January 16, 2007 Crystal Sage does this all the time. I think it borders on spam. Mods don't seem to care about all the commercial links he/she posts, but they'll knock others down in a FLASH. Maybe I should get this moved to the conspiracy area.................? Link to comment Share on other sites More sharing options...
frogfish Posted January 16, 2007 #14 Share Posted January 16, 2007 Are Lab made... sythetic vitamins as healthy as the real thing??? Who even said all natural remedies are side-effect free? Medicine is many times more effective than purely natural remedies. Link to comment Share on other sites More sharing options...
The Skeptic Eric Raven Posted January 16, 2007 #15 Share Posted January 16, 2007 Crystal Sage does this all the time. I think it borders on spam. Mods don't seem to care about all the commercial links he/she posts, but they'll knock others down in a FLASH. Maybe I should get this moved to the conspiracy area.................? Thankyou.I thought I was the only one that noticed that. Link to comment Share on other sites More sharing options...
crystal sage Posted January 16, 2007 Author #16 Share Posted January 16, 2007 Thankyou.I thought I was the only one that noticed that. I'm just quoting real research /findings as I haven't any real scientific training and am just curious about things... I can't just say' maybe this is so' ... with out anything to back up these ideas....hence the beauty of the internet... You can ponder about anything... take a look and find what others have shared about their discoveries...knowledge their parents... have passed down... scientists discoveries over the years... it's wonderful!!! I so wished this level of internet were available when my Father got cancer.. and some of me few close friends... This is a sharing and learning tool for me... 18 months ago when I first learned how to use the internet.. I was in extreme pain...almost consigned to a wheel chair..and didn't know what was wrong with me..nor did the doctors...I had MRIs various tests...they saw lots of little things...and were slowly ruling one thing out after the other... but it was getting harder as each day any step I took was more painful..everything was hurting more and more... One of my kids showed me how to use the computer..( was a little frightened of it before... I mentioned on another thread here about a year ago..how I had problems with electrics when I was stressed... LOL... probably in the Ghosts and Hauntings section... or the Metaphyisics...)... any way for the first time the computer wouldn't freeze or crash when I got near it.,.. and then within a few months of accidently...co-incidently?? finding interesting info on toxins... health... I slowly was able to select the relevant info to reverse whatever damage afflicted me...now I'm about 80% to 90% healed!!! Link to comment Share on other sites More sharing options...
frogfish Posted January 17, 2007 #17 Share Posted January 17, 2007 I'm just quoting real research /findings as I haven't any real scientific training and am just curious about things... I can't just say' maybe this is so' Many papers you post either have no relevance or are not understanable by most here... finding interesting info on toxins... health... I slowly was able to select the relevant info to reverse whatever damage afflicted me...now I'm about 80% to 90% healed!!! So you healed yourself by reading papers on ths internet? Never heard that one before. Link to comment Share on other sites More sharing options...
crystal sage Posted January 17, 2007 Author #18 Share Posted January 17, 2007 Many papers you post either have no relevance or are not understanable by most here... So you healed yourself by reading papers on ths internet? Never heard that one before. LOL.. because there are no published medical papers on it??? Link to comment Share on other sites More sharing options...
frogfish Posted January 17, 2007 #19 Share Posted January 17, 2007 No, your papers actually have no relevance to the topic many times... Link to comment Share on other sites More sharing options...
eqgumby Posted January 17, 2007 #20 Share Posted January 17, 2007 I'm glad you feel better, but sometimes it's just too much, like that white powdered gold stuff. Sorry, but herbal remedies are not really unexplained mysteries. Link to comment Share on other sites More sharing options...
crystal sage Posted January 17, 2007 Author #21 Share Posted January 17, 2007 I'm glad you feel better, but sometimes it's just too much, like that white powdered gold stuff. Sorry, but herbal remedies are not really unexplained mysteries. Mainly it was just cutting out all aspartame products . http://www.dorway.com/indexnew.html .. painting on some potassium iodide... accasionally http://www.annieappleseedproject.org/ioddefarbyro.html and some myotherapy treatments... What is Myotherapy? "Myotherapy is a 'trigger point' therapy. It involves pressing on small, constricted, sore points that trigger pain in areas away from the points. For example, a tense, painful know of muscles in teh neck might cause pain in the head. In this case, myotherapy would involve pressing on the knotted neck muscles to decrease pain in the head. Myotherapy was developed by prominent physical therapist Bonnie Prudden in 1976. It is very similar to acupressure. The main difference between acupressure and myotherapy is that myotherapy is based upon manipulation of muscle and acupressure is based upon nerves and energy meridians. How are Trigger Points Defused? To defuse "trigger points," pressure is applied to the muscle for several seconds by means of fingers, knuckles and elbows. The success of this method depends on the use of specific corrective exercise for the freed muscles. How are Trigger Points created? It is belived that Trigger Points are created by injuries, muscle strain and emotional stress. Sometimes trigger points can lie dormant and don't cause pain until they are activated by physical or emotional stress. Will the Trigger Points go away? Yes. Through many sessions of myotherapy, trigger points can be eliminated. It is important to take preventative measures like muscle stretching and decreasing stress to keep trigger points from returning." Link to comment Share on other sites More sharing options...
crystal sage Posted July 18, 2008 Author #22 Share Posted July 18, 2008 (edited) http://www.newscientist.com/channel/health.../mg18624984.500 One weed takes on two killer cancers * 07 May 2005 * Rachel Nowak * Magazine issue 2498 A WEED extract that has already shown promise as a treatment for skin cancer might also help treat one kind of leukaemia. The weed is petty spurge (Euphorbia peplus), which has long been used to treat warts and corns. An extract of petty spurge, ingenol 3-angelate or PEP005, developed in Australia by the Brisbane-based company Peplin, produced impressive results when applied directly to skin cancers in animals. Initial human trials of the compound as a treatment for non-melanoma skin cancers, the most common form of cancer worldwide, are under way. Lab tests had hinted that PEP005 might also be effective against leukaemia cells, so a team at the University of Birmingham in the UK decided to test it against cancer cells taken from eight patients with acute myeloid leukaemia, a particularly aggressive, difficult-to-treat cancer of bone marrow stem cells. It worked in seven of the eight samples, killing between 56 ... http://en.wikipedia.org/wiki/Actinic_keratosis http://www.ncbi.nlm.nih.gov/pubmed/17264770 Ultimately, ingenol 3-angelate (I3A) of PEP005, emerged as a promising potential new anti-cancer treatment. Here we report the proceedings from the First International Conference on PEP005, covering the exciting potential of PEP005 as the therapeutic agent for the treatment of skin cancer, leukemia and bladder cancer. http://www.biotechnologynews.net/storyview...?storyid=265500 Peplin in Phase 2b for PEP005 Thursday, 26 June 2008 PEPLIN has begun treating the first patient in the company’s Phase 2b clinical trial of actinic (solar) keratosis treatment PEP005. Edited July 18, 2008 by crystal sage Link to comment Share on other sites More sharing options...
crystal sage Posted January 2, 2009 Author #23 Share Posted January 2, 2009 It's getting there.... Peplin's skin cancer gel trial a success http://www.theage.com.au/news/Business/Pep...6335660056.html Mr Aldridge said it was the first time the molecule from petty spurge had been used to treat BCCs, which are usually surgically removed. "We've seen some very, very impressive results," he said. "This is the first time two days of therapy have shown to be effective in clearing skin cancers." Peplin Completes Enrollment for its First Phase III AK Clinical Trial http://www.fiercebiotech.com/press-release...-clinical-trial http://www.modernmedicine.com/modernmedici...l.jsp?id=563266 the treatment requires fewer applications, a shorter period of time and more rapid resolution of side effects, with at least as good or better efficacy," Dr. Anderson says. Ingenol mebutate was developed in Australia in the late 1990s, and if all goes well with the current FDA phase 3 trial for nonface applications and the phase 3 trials for face and scalp applications slated to begin early next year, the treatment may soon be available in the United States. Imiquimod is currently being used for superficial BCCs and SCCs, so, theoretically, ingenol mebutate may also be tried for these skin cancers. Dr. Anderson says that given the nature of the cellular necrosis mechanism of this drug, it may actually prove to be an even more efficient therapy in thicker tumors than other topicals, such as imiquimod. Link to comment Share on other sites More sharing options...
crystal sage Posted June 23, 2009 Author #24 Share Posted June 23, 2009 Still looking good... Positive Results for Peplin`s First Phase III AK Trial http://www.reuters.com/article/pressReleas...2009+BW20090518 Dr. Robert Rosen, a Sydney dermatologist and scientific advisor to Peplin, who has also been involved in the PEP005 clinical trial program, said that current treatment options for solar keratosis have a number of shortfalls, including pain, persisting skin irritation and redness during prolonged treatment periods. "As a result, patients are often unwilling to use their medications," he said. "A topical agent like PEP005 Gel, which can effectively and conveniently treat lesions in two days, will be of significant benefit to doctors and their patients." and works on age spots too!!! http://news.smh.com.au/breaking-news-natio...90518-bccm.html http://www.news.com.au/couriermail/story/0...67-3122,00.html analysts gave the thumbs up to last week's Phase III results on 255 patients with sunspots, some of which could turn into skin cancers. Further trials are still being conducted for the big market – the face and scalp. Peplin shares have cooled after enthusiasm for last week's trials, closing Friday at 67¢. Lesions were totally cleared on 27 per cent of patients. About 44 per cent recorded clearance of more than three-quarters of lesions after 57 days. "The product maintained (a) favourable safety profile," Wilson HTM analysts Shane Storey and Graeme Wald wrote. Peplin's gel was used in treatment over two days, while rivals' creams or gels are used between one to four months. Link to comment Share on other sites More sharing options...
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