hmm...not sure...the thing about mutation is that it's a one of flaw in the genetic characteristics. A mole (as in those horrible little things that you sometimes get on your skin) is a mutation, for example. It's not actually what an organism is supposed to be like, and more often than not, they're either very rare...you're unlikely to find a mutation that will change a creature's genetic structure so much that it could miraculously survive in toxic conditions. The effects are usually detrimental.
Natural selection, however, is the process that works upon natural characteristics of an organism...variation exists as a part of nature, and those who's characteristics are more suited to their environment are better suited to survive there, and pass on their genes to the next generation...thus, those genes for surviving will be more and more expressed as the generations go on, and those without them wither and die.
A high pollution environment would have a hand in the course a species took...but no more than any other environment. Every niche involves this 'survival of the fittest' system (except among humans, who seem to have eliminated it...which is probably why our evolution will be halted for the forseeable future...which isn't a huge problem, until the chimps catch up

).
Of course, you then have to remember that nature wouldn't have much to work with, as a high pollution environment would kill most organisms long before their gene pool had specialised to survive in it.