Would you care to comment on why Ankhesenamun would have considered making a Hittite prince king of Egypt, effectively placing Egypt under foreign rule? Nefertiti is certainly speculated to have been of foreign origins, in which context it would make sense that she may have desired to have a non-Egyptian husband.
IIRC, Horemheb was the presumed heir-apparent of Tutankhamun, but was out maneuvered by Ay, whom once again was a commoner by birth. Therefore Ay had no legitimate claim to the throne. Horemheb, himself, upon acquiring the throne (from Ay's presumed heir-apparent Nakhtmin) erased much concerning the entire Amarna Period and those involved. Regardless of Ankhesenamun's opinion of Horemheb, she wouldn't have wanted a commoner (Ay) upon the throne, and as Suppiluliuma was known as a very strong king in his own right, might have tried to enlist his aid (by way of a son) to curtail if not prevent the situation from degrading any further.