At the heart of science is an essential balance between two seemingly contradictory attitudes--an openness to new ideas, no matter how bizarre or counterintuitive they may be, and the most ruthless skeptical scrutiny of all ideas, old and new.
This is how deep truths are winnowed from deep nonsense. -- Carl Sagan
'His pain of mind was most pitiable to see. It was the mental torture of a conscientious man oppressed beyond endurance by an unintelligable responsibility involving life'. from 'The Signalman' by Charles Dickens