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Pineal health...


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#1    crystal sage

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Posted 13 February 2007 - 11:43 PM

cool.gif   A question for you scientists.... will Seratonin uptake inhibitors prevent... or lower the production of Melatonin????




Melatonin is a hormone manufactured from serotonin and secreted by the pineal gland, which is a pea-sized gland at the base of the brain. As people age, sometimes the pineal gland will calcify, causing a decrease in melatonin production. It is made from the amino acid tryptophan. Your body needs B vitamins to convert melatonin from tryptophan. If you do not get enough B vitamins your body could be deficient in melatonin. At menopause there is a decline in melatonin production. Melatonin influences sleep, mood, the stress response, immune function, and even helps to prevent cancer.

http://www.aurorahealthcare.org/yourhealth...2221811.html%22

http://www.springerlink.com/content/r47518675jw057j0/
thumbsup.gif Interesting!!!! The Appenix produces melatonin!!!! I had always heard that they were a useless organ... used originally for digesting grass!!!!!..eg as a cow supposedly has a huge one!!!!!

"The concentration of melatonin in the gastrointestinal tissues surpasses blood levels by 10–100 times and there is at least 400× more melatonin in the gastrointestinal tract than in the pineal gland."


The human appendix was the first site outside the pineal where the occurrence of melatonin could be demonstrated (Raikhlin et al: “Melatonin may be synthesized in enterochromaffin cells.” Nature [Lond.] 1975,255:344-5.) The biosynthesis of melatonin was demonstrated in the gut the following year ( Quay & Ma: “Demonstration of gastrointestinal HIOMT.” Int. Rep. Clin. Sci. Med. Sci. Lib. Compend. 1976, 4: 563.) Melatonin is widely available as an individual food supplement.

Edited by crystal sage, 14 February 2007 - 12:27 AM.


#2    frogfish

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Posted 14 February 2007 - 12:25 AM

The amount of melatonin created by the appendix is insignificant however.

removal of this organ has no effects on humans.

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#3    crystal sage

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Posted 14 February 2007 - 12:47 AM

http://www.the-scientist.com/article/display/20981/

http://www.annalsnyas.org/cgi/content/abstract/917/1/376


Beyond Health Articles -The Hazards of Painkillers (NSAIDS)
Here's one mechanism by which NSAIDS damage gut tissue. NSAIDS work by blocking the action of messenger ... NSAIDS also interfere with melatonin production


http://carcin.oxfordjournals.org/cgi/content/full/25/6/951

Edited by crystal sage, 14 February 2007 - 01:01 AM.


#4    crystal sage

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Posted 14 February 2007 - 01:03 AM

Quote

The amount of melatonin created by the appendix is insignificant however.

removal of this organ has no effects on humans.




Thanks... I couldn't find much more on it...but it was quite interesting.....

With the incidents of depression etc. increasing... I was wondering if people without appendix were more prone to depression than those with????

and it is interesting that the gut is said to work similar to the pineal glands ie.. in melatonin and seratonin production...so it explains why sometimes you get stomache upsets with some depressants... and the new links and research of stomache brain connection with IBS sufferers...  

the Abdominal Brain....   http://www.meridianinstitute.com/ceu/ceu12abd.html



Edited by crystal sage, 14 February 2007 - 01:11 AM.


#5    crystal sage

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Posted 14 February 2007 - 02:39 AM

wink2.gif   some seratonin music....

http://whozoo.org/mac/Music/5HTT.htm


#6    Opus Magnus

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Posted 15 February 2007 - 03:09 AM

Quote

The amount of melatonin created by the appendix is insignificant however.

removal of this organ has no effects on humans.


Maybe by removing the appendix the pineal gland takes over the appendix's production.  Kind of like how if you lose one testicle the other one will start to produce more fluids to compensate.


#7    crystal sage

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Posted 15 February 2007 - 10:21 PM

http://www.vivo.colostate.edu/hbooks/pathp...ndo/pineal.html

"Seasonal changes in daylength have profound effects on reproduction in many species, and melatonin is a key player in controlling such events. "

...the pineal is similar to the adrenal medulla in the sense that it transduces signals from the sympathetic nervous system into a hormonal signal.

http://www.ncbi.nlm.nih.gov/entrez/query.f...p;dopt=Abstract
". It is suggested that, under physiologic conditions, the lamina propria plexus has a modulatory role between the epithelium and the deeper mural enteric nervous system mediated by serotonin neurotransmission. Uncontrolled release of serotonin by the plexus may initiate inflammation and elicit pain related to the appendix."
http://www.ncbi.nlm.nih.gov/entrez/query.f...p;dopt=Abstract
CONCLUSION: Plasma serotonin level is a reliable marker of acute appendicitis, especially in the first 48 hours.

PMID: 9167375 [PubMed - indexed for MEDLINE]

  thumbsup.gif        " Serotonin - a mediator (the chemical messenger) made by cells of a nerve in a brain, which is used by nerves to communicate with each other. The nerve releases serotonin whom it makes in a place environmental it. serotonin or travel across a place and the attache in receptors on a surface of nearby nerves or it attaches to receptors on a surface of a nerve which has made it to be taken a nerve and released again (the process named as re-uptake). Balance achieve serotonin between the appendix to nearby nerves and reuptake. Perfect inhibitors of serotonin block reuptake of serotonin and consequently change a level of serotonin in a brain. It is necessary, that there are some illnesses such as depression are caused by disorders in balance between serotonin and other mediators."
http://www.rxhelphere.com/sertraline.htm

huh.gif !! cool.gif ....could this mean that the appendix has a role in balancing the seratonin in the body???

and will  consequently....serotonin uptake inhibitors  " happy pills"  help stabilize appendicitis...?????

Edited by crystal sage, 15 February 2007 - 10:48 PM.


#8    crystal sage

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Posted 15 February 2007 - 10:26 PM

thumbsup.gif http://flash.lymenet.org/scripts/ultimateb...f=1;t=051925;p=


  "From personal experience...kids and husband...all have had their appendix out...

more PRONE to depression.

Research serotonin - appendix. You may have to dig deep to find it.

May need "help" (as in 5HTP supp.) if NOT on Prozac.

IMO...far better to give the NUTRIENTS to make serotonin and let the body decide rather than to keep serotonin high...ongoing.

Prozac use now (very recent) linked to osteoporosis.

The levels are supposed to fluctuate as needed.

It should go without saying...be SURE to take probiotics as post surgery abx. will impact the "good guys". Take them one hour BEFORE meals with a full glass of water (to dilute stomach acids so they don't destroy the beneficial bacteria). "

LYME disease and appendix connection !!!!!!!

peoples comments...

thumbsup.gif !!!!!!!!!..."I remember reading a thread here on LymeNet once and I was surprised at the number of Lyme patients who had their appendix taken out."

"Wow! Thanks for this post! My appendix ruptured six months before I flared hard with Lyme.

They did an emergency surgery and I was on IV vancomycin for 7 days. I had the sweats and chills bad (Babesia?) and couldn't recover quickly.

My incision was from navel to pelvis (I look like a stuffed animal now) and it got badly infected and I was put on Levaquin and had bad tendon reactions and further fatigue and malaise (Bartonella?!).

It took 5 months before I started to feel a little better and then I got bitten by another tick! I got "ticked" when I was already down!

Makes you say "hmmmm...."

Thanks for talking about this topic,"


http://www.healthboards.com/boards/showthread.php?p=2157105


Lyme disease symptom... ???? !!....Dxd Neurotransmitter Deficent with almost non existent levels of Seratonin,



Edited by crystal sage, 15 February 2007 - 10:40 PM.


#9    crystal sage

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Posted 15 February 2007 - 10:44 PM

"To make matters worse, prescription drugs that are used to address neurotransmitter deficiencies are depleting the neurotransmitters in the brain. For example, depression may be caused by an imbalance of Seratonin. Medications classified as Selective Seratonin Reuptake Inhibitors (SSRI) are prescribed to address the symptom of depression. SSRI's prevent Seratonin from being reabsorbed by the sending nerve cell, keeping it available for the receiving nerve cell. If the Seratonin is not received or reabsorbed by either cell, the body will inactivate it, over time depleting the level of Seratonin in the body. Long-term use of these drugs will cause greater imbalance, and a total system crash."

http://www.colecenter.com/newsletter/neuro...rsdetoxdiet.htm


#10    crystal sage

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Posted 15 February 2007 - 11:00 PM


BREAST HEALTH TIP #17: Sleep Go to bed by 10PM, pull down the shades and turn off all the lights.

http://www.healthy.net/scr/Column.asp?Id=692
A study published in the Journal of the National Cancer Institute in 2001 found nurses that worked the night shift had a 50% increased risk of breast cancer. The longer they worked the night shift, the higher their risk of breast cancer became. The reason is simple. It has to do with the daily rhythms of the sun and the hormone "melatonin." Melatonin is extremely powerful at protecting against and fighting breast cancer - but only if you go to bed early and it's dark.

Scientists have discovered that when it gets dark the pineal gland in our brain produces more melatonin. As this hormone rises, you start to feel sleepy. The moment you fall asleep the level of melatonin goes much higher. But here's the catch - melatonin doesn’t rise very high unless you’ve gone to bed by 10 pm and it's dark.

The darker it is, the higher your melatonin will rise. Any type of light-even a soft night light can keep your melatonin levels from rising very high. Researchers think that is why breast cancer is more common in industrialized regions where city lights burn all night and why blind women have a 50% lower incidence breast cancer than women who can see.


#11    crystal sage

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Posted 19 February 2007 - 12:17 AM

Brazil nuts... a good source of selenium


http://www.earthclinic.com/CURES/MS.html


http://www.encyclopedia.com/doc/1G1-99185855.html


"Because brazil nuts and methionine are known to be safe," the ... It plays a crucial role in the production of the brain chemicals serotonin and melatonin,
http://www.motherjones.com/news/feature/2000/01/pandora.html


http://www.howweheal.com/protein.htm


thumbsup.gif
  

Perfect mood food... Turkey with  Cranberry Brazil nut Relish

Try and use Agar Agar instead of gelatin for extra health benefits.... http://www.great-workout.com/nutrition/veg...ition-facts.cfm



Cranberry Brazil Nut Relish
1 envelope unflavored gelatin         1/2 c. cold water              boiling water
1 c. cranberry juice                        2 c. fresh cranberries        1/2 c. sugar
1/4 t. salt                                       1/2 c. chopped Brazil nuts    1/2 c. diced celery

Sprinkle gelatin over cold water.  Let stand 5 minutes.  Place over boiling water, stirring until gelatin is dissolved.  Remove from heat.
Stir in cranberry juice.  Refrigerate until it's the consistency of unbeaten egg whites (approx. 1 hr.).             Chop cranberries & add sugar & salt.  Mix well.  Gently fold this mixture as well as the nuts & celery into the gelatin mixture.  Turn into 1 qt. serving dish & chill until firm.


http://paleofood.com/stuff.htm


#12    crystal sage

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Posted 19 February 2007 - 12:21 AM

The Healing Power of Light

Photoluminescence: UV Lght Irradiation in the Laboratory

by E.W: McDonagh, D.O.

http://www.lightparty.com/Health/HealingLight.html


"some people the pineal gland begins to calcify as young as 6yrs of age. It is very common in adults. As most of you are already aware of, the pineal is probably one of the most important glands as far as OBE's, LD's and psychic development are concerned. So you certainly want it 'in the pink' of health so to speak.

Calcification of the pineal gland is so prevalant in adults that it really got me to thinking. It seems that some people at a certain age see a decline in LD's and OBE's. Is there a connection? I have already read about how testosterone increase seems to lead to more LD's. So there appears to be a hormonal connection at least, perhaps.

But wait. We also produce less melatonin as we age. Melatonin is produced by the pineal gland. People who increase melatonin have reported more vivid dreams, and more lucid dreams. I have noticed an increase in OBE's myself with dietary means alone (to increase melatonin). So, anyway, I have been searching the net trying to find ways of decalcifying the pineal gland.

This is what I have found so far. Turmeric, frankencense and oral chelation therapy are said to aid in the decalcification of the pineal gland. I am sure the headstand or other inversion type exercises would'nt hurt either. I only post this because this information might benefit certain people who seem to be getting nowhere having tryed everthing. "

http://forums.astraldynamics.com/viewtopic...bb032fe3412cf7e

http://www.i-c-m.org.uk/journal/2005/feb/a01.htm

Turmeric’s curcurmin curries much favour with Alzheimer’s – and other illnesses


http://www.nbay.eu/frankincense_in_aromath...oils-15476.html

Frankincense resin is thought to have a bounty of health properties - it was an ingredient in a ... the hypothalamus, the pineal and the pituitary glands. .

Edited by crystal sage, 19 February 2007 - 12:37 AM.


#13    crystal sage

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Posted 14 March 2007 - 10:19 PM

http://www.gdx.net/home/assessments/melato...ide/index2.html
Light Exposure

Light exposure of the retina alters the amount of serotonin metabolized to melatonin, via the neural pathways that connect the retina to the pineal gland.9 The individual's visual system must be intact for proper synchronization of the melatonin rhythm. Blind persons commonly exhibit a pronounced lack of circadian rhythm, with free-running cycles generated internally despite the presence of other external time cues in their environment.10,11

Exposure to sufficient levels of light at night can rapidly reduce melatonin production.12 One investigator found that after human subjects were exposed to one hour of light at midnight using 3000, 1000, 500, 350, and 200 lux intensities, melatonin levels dropped by 71, 67, 44, 38, and 16% respectively.13

The spectrum of light that most dramatically inhibits melatonin secretion is green band light (540nm), which corresponds to the rhodopsin absorption spectrum in humans.14 This observation is of considerable importance, not only to understand the physiological effects of melatonin, but to effectively regulate circadian rhythms- a crucial component in the treatment of Seasonal Affective Disorder (SAD) and other health problems.15\




Effect of Drugs

Antidepressants and other psychotropic drugs affect the synthesis and release of melatonin. Some monoamine oxidase-inhibiting drugs such as clorgyline and tranylcypromine seem to enhance plasma melatonin levels, while others, such as deprenyl, register no significant change.27-30

Tricyclic antidepressants that influence monoamine uptake and beta-adrenoceptors trigger a decrease in plasma melatonin in rodent experiments; however, human patients treated with the tricyclic desipramine show either no change, or a notable rise, in nighttime melatonin levels.27,30 Although tricyclics and fluvoxamine are both associated with increases in melatonin secretion in humans, fluoxetine (commonly known as Prozac) reportedly lowers blood melatonin levels.31

One group of researchers conjectured that sleep disruption associated with some nonsteroidal anti-inflammatory drugs (NSAIDS) such as aspirin, ibuprofen, and acetaminophen may be a result of decreased prostaglandin production, which can suppress melatonin secretion.32 Both ibuprofen and indomethacin significantly reduce melatonin plasma levels and delay the nocturnal rise of the circadian rhythm.33,34

ß-blockers can also significantly alter melatonin levels. Hypertensive patients undergoing chronic beta-adrenoreceptor blocker treatment with propranolol and ridazolol showed considerably diminished melatonin secretion.35 Propranolol hydrochloride also induced a noticeable decrease in serum melatonin levels in schizophrenic patients.36


#14    crystal sage

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Posted 14 March 2007 - 10:22 PM

Cancer

There is good evidence for photoperiod dependence and/or melatonin responsiveness in the initiation and evolution of certain cancers, particularly hormone-dependent cancers. Administration of melatonin significantly improved survival time and quality of life in patients with brain metastases due to solid neoplasms.60 When used after first-line chemotherapy (cisplatin) for treating nonsmall cell carcinoma (NSC) of the lung, melatonin also successfully prolonged the survival time for patients with metastatic NSC lung cancer.61

Because of its powerful oncostatic effects and its estrogen-blocking ability, melatonin demonstrates particular promise in the treatment of breast cancer. Numerous studies have reported an inverse correlation between melatonin levels and the growth of estrogen-receptive positive tumors.62-66 Used in conjunction with tamoxifen to modulate cancer endocrine therapy, melatonin shows marked ability to modulate estrogen receptor expression and inhibit breast cancer cell growth. Moreover, researchers surmised that melatonin may induce objective tumor regressions in metastatic breast cancer patients refractory to tamoxifen alone.67
Immune System

When properly administered, melatonin has general stimulatory effects on immune system functions; its positive anti-cancer effects may stem from this strengthening of the immune response.68 One theory is that melatonin acts as an anti-stress hormone via the brain opioid system, with consequent up-regulation of the immune system.69,70

Many researchers believe that T-derived cytokines are the main mediators of the immunological effect of melatonin. Specific high affinity binding sites for 125I-melatonin have been discovered on T-helper-type 2 lymphocytes in the bone marrow and in various lymphoid tissues.71,72
Multiple Sclerosis

Multiple Sclerosis (MS) is the most common of the demyelinating diseases of the central nervous system. The clinical course and prognosis of the disease is variable, although it typically tends to progress in a series of relapses and remissions. In most cases, a patient with MS undergoes a slow and steady deterioration of neurological function.

Recently, the pineal gland has been implicated in the pathogenesis and clinical course of MS. When melatonin levels decline, an exacerbation of MS symptoms is seen.73,74 Remission effects in MS are thought to relate to the stimulatory influence of melatonin on the immune system.

http://www.gdx.net/home/assessments/melato...ide/index3.html


#15    frogfish

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Posted 14 March 2007 - 10:36 PM

There are other and more effective ways to deal with esterogen and androgen-dependent cancer. Plus, there's always the risk of hormone-refractory cancer.

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