A study on mice found that the equivalent of drinking two cups of coffee and then exercising dramatically reduced the number of sun-damaged cells that can lead to cancer. In the experiments, one group of hairless mice drank caffeinated water, another exercised on a running wheel and a third group drank and ran on the wheel. All three groups were exposed to cell damaging UVB radiation, the equivalent of spending 15-30 minutes outdoors at midday.
Cell death or apoptosis, the body's way of killing off DNA-damaged cells, was observed in all three groups. But the group of mice that drank caffeine and exercised had a 400 per cent increase in cell death, versus 120 per cent for the exercisers and 95 per cent increase for the caffeine drinkers.
The studies, conducted in the Susan Lehman Cullman Laboratory for Cancer Research at Rutgers' Ernest Mario School of Pharmacy, will appear in the July 31 Proceedings of the National Academy of Sciences.
They follow previous studies that showed both caffeine and exercise in isolation inhibited ultraviolet light-induced skin cancer. Caffeine has been linked to a reduction in liver cancer and breast cancer, and exercise has been shown to reduce the risk of colon cancer, among others.
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