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http://www.sciencedaily.com/releases/2008/...80507084013.htm
ScienceDaily (May 8, 2008) — A common weedkiller in the U.S., already suspected of causing sexual abnormalities in frogs and fish, has now been found to alter hormonal signaling in human cells, scientists from the University of California San Francisco (UCSF) report.
The UCSF study is the first to identify its full effect on human cells. It is being reported in the May 7 issue of the journal "PLoS One."
In studies with human placental cells in culture, the UCSF scientists found that atrazine increased the activity of a gene associated with abnormal human birth weight when over-expressed in the placenta. Atrazine also targeted a second gene that has been found to be amplified in the uterus of women with unexplained infertility.
In parallel studies of zebrafish, a widely used animal in development studies, the research team showed that atrazine "feminized" the fish population -- increasing the proportion of fish that developed into females.
ScienceDaily (May 8, 2008) — A common weedkiller in the U.S., already suspected of causing sexual abnormalities in frogs and fish, has now been found to alter hormonal signaling in human cells, scientists from the University of California San Francisco (UCSF) report.
The UCSF study is the first to identify its full effect on human cells. It is being reported in the May 7 issue of the journal "PLoS One."
In studies with human placental cells in culture, the UCSF scientists found that atrazine increased the activity of a gene associated with abnormal human birth weight when over-expressed in the placenta. Atrazine also targeted a second gene that has been found to be amplified in the uterus of women with unexplained infertility.
In parallel studies of zebrafish, a widely used animal in development studies, the research team showed that atrazine "feminized" the fish population -- increasing the proportion of fish that developed into females.
