Oh, there's significance, all right. They're recognized symbols that are still being used today, though the symbol for "Air" is actually the Astroloigcal Symbol for Sol, or our sun.
EDIT 1: Actually, now that I think of it, it's both for Air AND the sun.
As for other ones:
Travel is correct.
Goddess is correct.
Fate is correct.
War is correct.
God and Death are correct. (Not very sure about Death.) Fire and Love appear to be wrong, though I might be wrong on Love.
Everything except Possession and Water are correct, but then again, I'm not sure on those two.
The underworld one appears to be completely made up! I've never seen it before in my life.
Victory appears to be correct.
Oh, and for Isaac's legend, I think this was actually one of the first ouija board designs. And the zodiac-esque symbols were taken off of the other designs after this design due to the symbols giving the spirits some sort of power that _could_ be used maliciously.
Use it with caution. Use them together. Use them in... good... faith? Will? Uh, how'd that Spock quote go?