According to THQ's website, there will be new weapons, mind powers, cities, and humans. Also, old weapons like the Zap-O-Matic are getting a new destructive makeover.
New weapons are The Meteor Strike, Gastro Gun, and Dislocator.
New cities are Albion(London), Tunguska(Russia), Takoshima Island(Tokyo), and Bay City(San Fransisco). Also, Bay City was the idea for a city in the first game, but was dropped. So they are using it in this game.
New mind powers are Transmogrify, Mind Flash, and Body Snatch.
New humans will be hippies, spies, and ninjas.
Destroy All Humans! 2 at THQ.com

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