A daisy-like plant known as Feverfew or Bachelor's Button, a traditional remedy for reducing fevers and a treatment for nervousness, hysteria and low spirits, is the source of an agent that kills human leukemia stem cells like no other single therapy, scientists at the University of Rochester Medical Center's James P. Wilmot Cancer Center have discovered. Their investigation is reported in the online edition of the journal, Blood.

It will take months before a useable, pharmaceutical compound can be made from parthenolide, the main component in Feverfew. However, UR stem cell expert Craig T. Jordan, Ph.D., and Monica L. Guzman, Ph.D., lead author on the Blood paper, say their group is collaborating with University of Kentucky chemists, who have identified a water-soluble molecule that has the same properties as parthenolide.

The National Cancer Institute has accepted this work into its rapid access program, which aims to move experimental drugs from the laboratory to human clinical trials as quickly as possible.

"This research is a very important step in setting the stage for future development of a new therapy for leukemia," says Jordan. "We have proof that we can kill leukemia stem cells with this type of agent, and that is good news."

Parthenolide is the first single agent known to act on myeloid leukemia at the stem-cell level, which is significant because current cancer treatments do not strike deep enough to kill mutant cells where the malignancy is born.

In other words, even the most progressive leukemia treatment, a relatively new drug called Gleevec, is effective only to a degree. It does not reach the stem cells, so "you're pulling the weed without getting to the root," Jordan says.

Feverfew has been used for centuries as an herbal remedy to reduce fevers and inflammation, to prevent migraine headaches, and to ease symptoms from arthritis. (A person with leukemia, however, would not be able to take enough of the herbal remedy to halt the disease.)

Investigating stem cells that give rise to cancer is an urgent new initiative, as is identifying stem-cell treatments that might end the disease process. Jordan and Guzman are among only a handful of stem cell biologists nationwide who are specifically studying cancer stem cells. In recent years, scientists have identified cancer stems cells in blood cancers and in brain and breast tumors - although the idea that cancer stems cells exist has been around for at least 40 years.

In the current study, the UR group began investigating Feverfew after other scientists showed that it prevented some skin cancers in animal models. Intrigued by the plant's anti-tumor activities, the UR team analyzed how a concentrated form of parthenolide would act on the most primitive types of acute myelogenous leukemia cells, chronic myelogenous leukemia cells and normal cells.

In laboratory experiments, they also compared how human leukemia stem cells reacted to parthenolide, versus a common chemotherapy drug called cytarabine. The result: parthenolide selectively killed the leukemia cells while sparing the normal cells better than cytarabine.

Scientists believe parthenolide might also make cancer more sensitive to other anti-tumor agents. And, the UR group was able to demonstrate the molecular pathways that allow parthenolide to cause apoptosis, or cancer cell death, increasing the chances of developing a new therapy.

Jordan is director of the Translational Research for Hematologic Malignancies program at the Wilmot Cancer Center and associate professor of Medicine and Biomedical Genetics. Guzman is senior instructor of hematology/oncology.

Other co-investigators include: Randall Rossi, associate scientist; Lilliana Karnischky, laboratory technician; Xiaojie Li, technical associate; Derick Peterson, Ph.D., assistant professor of biostatistics, and Dianna Howard, M.D., at the University of Kentucky Medical Center.

http://www.urmc.rochester.edu/

http://www.news-medical.net/?id=7909

Great stuff Crystal Sage. Herbal medicine is great and a very interesting field. Just one of the many reasons I hate to see the biodiversity in the tropics reduced through destruction of habitat. Who knows what herbal cures are left to be discovered.

This has been used for eons to help reduce migraines. I've been taking it on and off for years, so far no lukemia! Glad to hear it has other good effects.

When I first read this I thought it said, "is the source of an agent that kills A human"! Had to read it a couple times...

That along with your spoon full of sugar!!!! and you're laughing...

http://www.alternativehealthsecrets.com/Glyco.htm

http://www.glyconutritionforlife.org/what_are.php

Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells

http://mct.aacrjournals.org/cgi/content/abstract/5/2/296



http://linkinghub.elsevier.com/retrieve/pi...30438350500813X

The melanoma B16 cells were much more sensitive to berberine treatment than ... on a different length of a cell cycle), on the specific drug sensitivity and ...

Except this would be useless when Leukemia reaches the metastatic stage. Gilvec is a better drug to take...It actually targets the translocation responsible for Leukemia.

Maybe a blend of Feverfew...Berberine and Comfrey????

http://www.doctoryourself.com/comfrey_herb.html

http://www.redmoonherbs.com/articles/Comfrey-article.php

This is they key. Nothing can be done once leukemia is metastatic.

http://www.cancerx.org/science_of_bloodroot.html

http://www.lef.org/protocols/prtcls-txt/t-prtcl-027.html

"Because of this stress and the overload of toxins, you end up with a malfunctioning immune system, and a body that is not capable of destroying the excessive numbers of cancerous cells that develop. Some, sooner or later, survive and multiply. And then you have cancer. Of course, our diets loaded with sugar and refined carbohydrates don't help. Refined carbohydrates digest so fast they act like sugar, and cancer cells love sugar. They have about 8 times more receptor cells for capturing sugar than healthy cells."

"An underlying cause of cancer is low cellular oxygenation levels. In newly formed cells, low levels of oxygen damage respiration enzymes so that they cells cannot produce energy using oxygen. These cells can then turn cancerous.

In 1931 Dr. Warburg won his first Nobel Prize for proving cancer is caused by a lack of oxygen respiration in cells. He stated in an article titled The Prime Cause and Prevention of Cancer that "the cause of cancer is no longer a mystery, we know it occurs whenever any cell is denied 60% of its oxygen requirements."

"Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar. All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation. All normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes."

Poor oxygenation comes from a buildup of carcinogens and other toxins within and around cells, which blocks and then damages the cellular oxygen respiration mechanism. Clumping up of red blood cells slows down the bloodstream, and restricts flow into capillaries. This also causes poor oxygenation. Even lack of the proper building blocks for cell walls, essential fatty acids, restricts oxygen exchange.

(This is why the flax oil in cottage cheese treatment popular in Europe - 2 tablespoons of organic, refrigerated flax oil or freshly ground flax seed mixed in some cottage cheese - has become a well known cancer treatment. It provides essential fatty acids needed by cell walls so that oxygen can enter the cells.)

What Warburg and other scientists found was that respiratory enzymes in cells, which make energy aerobically using oxygen, die when cellular oxygen levels drop.

When this happens, the cell can no longer produce energy aerobically. So, if the cell is to live, it must, at least partially, ferment sugars, producing energy anaerobically.

According to Warburg, cells that produce energy by fermenting sugars may turn cancerous. Warburg's contention is this...

The cells that cannot produce energy aerobically, cannot produce enough energy to maintain their ability to function properly. So they lose their ability to do whatever they need to do in the body.

Fermentation allows these cells to survive, but they can no longer perform any functions in the body or communicate effectively with the body. Consequently, these cells can only multiply and grow. And may become cancerous. Or perhaps it would be more accurate to say, they change into cancer cells.

Decades ago, two researchers at the National Cancer Institute, Dean Burn and Mark Woods, (Dean translated some of Warburg's speeches) conducted a series of experiments where they measured the fermentation rate of cancers that grew at different speeds. What they found supported Dr. Warburg's theory. The cancers with the highest growth rates had the highest fermentation rates. The slower a cancer grew, the less it used fermentation to produce energy.

Naturally Warburg's contention was challenged and tested by other scientists.

Some researchers claimed his theory was not valid after they had measured a particularly slow growing cancer, and found no fermentation at all. And if cancer could grow with no fermentation, then fermentation, or lack of oxygen respiration, was not the cause of cancer. Dean Burn and Mark Woods checked those results.

Using more sophisticated equipment, they determined that the equipment these researchers used to measure fermentation levels was not accurate enough to detect fermentation at low levels. Their testing, using newer and more accurate equipment, showed that even in those very slow growing cancer cells, fermentation was still taking place, at very low levels.

Pietro Gullino, also at the National Cancer Institute, devised a test which showed that this slow growing cancer always produced fermentation lactic acid. Silvio Fiala, a biochemist from the University of Southern California, also confirmed that this slow growing cancer produced lactic acid, and that it's oxygen respiration was reduced.

Further research into Warburg's theory showed that when oxygen levels were turned down, cells began to produce energy anaerobically. They ultimately became cancerous when levels went low enough. It took a reduction of 35% in oxygen levels for this to happen.

J. B. Kizer, a biochemist and physicist at Gungnir Research in Portsmith, Ohio explains, "Since Warburg's discovery, this difference in respiration has remained the most fundamental (and some say, only) physiological difference consistently found between normal and cancer cells. Using cell culture studies, I decided to examine the differential responses of normal and cancer cells to changes in the oxygen environment.

"The results that I found were rather remarkable. I found that... "High 02 tensions were lethal to cancer tissue, 95 percent being very toxic, whereas in general, normal tissues were not harmed by high oxygen tensions. Indeed, some normal tissues were found to require high 02 tensions. It does seem to demonstrate the possibility that if the 02 tensions in cancer tissues can be elevated, then the cancer tissue may be able to be killed selectively, as it seems that the cancer cells are incapable of handling the 02 in a high 02 environment."

Low oxygen levels in cells may be a fundamental cause of cancer. There are several reasons cells become poorly oxygenated. An overload of toxins clogging up the cells, poor quality cell walls that don't allow nutrients into the cells, the lack of nutrients needed for respiration, poor circulation and perhaps even low levels of oxygen in the air we breathe.

Cancer cells produce excess lactic acid as they ferment energy. Lactic acid is toxic, and tends to prevent the transport of oxygen into neighboring normal cells. Over time as these cells replicate, the cancer may spread if not destroyed by the immune system.

Chemotherapy and radiation are used because cancer cells are weaker than normal cells and therefore may die first.

However, chemo and radiation damage respiratory enzymes in healthy cells, and overload them with toxins, so they become more likely to develop into cancer. The underlying cancer causing conditions are worsened, not improved. And the cancer usually returns quickly a second time unless you make changes to support the health of your body.

The implication of this research is that an effective way to support the body's fight against cancer would be to get as much oxygen as you can into healthy cells, and improving their ability to utilize oxygen. Raising the oxygen levels of normal cells would help prevent them from becoming cancerous.

And increasing oxygen levels in cancer cells to high levels could help kill those cancer cells.

A nurse who works in medical research said, "It's so simple. I don't know why I never thought of it before. When we're working with cell cultures in the lab, if we want the cells to mutate, we turn down the oxygen. To stop them, we turn the oxygen back up."

Ma Lan, MD and Joel Wallach DVD, point out that one type of white blood cells kills cancer cells by injecting oxygen creating hydrogen peroxide into the cells."

http://www.cancerfightingstrategies.com/print.html

Two words...BCR/ABL Translocation.

How about the TMPRSS2/ERG translocation in prostate cancer? How about hallmark translocations found in various MCF lines of Breast carcinomas?

Cancer has 7 different pathways!!!

maybe something in Glyconutrients will work here....

http://www.glycoscience.org/glycoscience/d....wm?&ID=719

I read something about an ingredient in Condor Grapes....

http://www.sciencedaily.com/releases/2002/...20522073916.htm

""My study is saying that there's another compound in grapes with equal cancer-fighting power as resveratrol, but which has antidiabetic properties as well," said Rimando. "The compound has always been in grapes, but no one has paid much attention to it."

Both pterostilbene and resveratrol belong to a group of chemicals called phytoalexins, which are produced by plants in response to fungal infection, ultraviolet light, and various chemical and physical stressors. While both exhibit strong antifungal activity, pterostilbene appears to be 60 to 100 times more potent as a fungicide, a property that may one day be exploited by farmers in search of a more disease-resistant grape, says Rimando.

In plants that contain these chemicals, their content usually differs dramatically. Quantitative studies have shown that for every 10 parts resveratrol, there's only about one to two parts pterostilbene. The relationship between the two similar compounds and their unequal content in plants is unclear, but remains the subject of ongoing studies, the researcher says.

Resveratrol has been found in many fruits, including blueberries and cranberries, but it is perhaps best known for its presence in grapes and red wine. Pterostilbene has so far been identified in grapes and in a relatively unknown medicinal plant, according to Rimando.

Dark-skinned grapes (such as red and blue-black) are likely to contain the most pterostilbene, while green grapes (also called white grapes) probably contain less, she says. "


http://www.bloodjournal.org/cgi/content/abstract/93/4/1245



http://www.medscape.com/viewarticle/508453_Figures

"To date, for two of the Siglec family members, MAG and CD22, the binding of the molecule to its sialic acid glycoprotein ligand is known to initiate intracellular signaling events. MAG and CD22 transduce cell surface events to intracellular signaling pathways by modulating the activity of protein tyrosine kinases (15, 50) or phosphatases (51). In each instance, the tyrosine residues within the intracellular domain are phosphorylated upon activation of the protein, and the phosphotyrosine then serves as a recognition site for the kinases or phosphatases by a SH2 domain. Tyrosine residues within the cytoplasmic domain of the B-cell restricted CD22 molecule are phosphorylated upon surface Ig or CD22 ligation (52, 53). Interestingly, while some of the phosphotyrosines on CD22 serve as docking sites for kinases, others are embedded within sequences recognized by the SH2 domains of phosphatases. The physiological relevance of the negative and positive regulatory functions can be inferred from the analysis of CD22-deficient mice. In the absence of antigen, CD22 negatively regulates B cell antigen receptor signaling; in the presence of antigen, CD22 positively regulates signaling by the antigen receptor (17, 54, 55)."

http://www.rhodes.edu/academics/4626.asp

"Finally, we are conducting an analysis of the enzyme asparaginase. Asparaginase is a key therapeutic agent for the treatment of acute lymphoblastic leukemia (ALL), but its mechanism and specificity are poorly understood. Using X-ray crystallography, kinetics, mutagenesis and bioinformatics, our goal is to generate more potent and stable enzymes for ALL treatment. We have already determined several high resolution structures of the enzyme from E. coli, including substrate complexes and site-directed mutants, to understand its mechanism and kinetics. We made the important discovery that asparagine is both a substrate and an allosteric positive effector of the enzyme.
Sickmier EA, Kreuzer KN, White SW. The crystal structure of the UvsW helicase from bacteriophage T4. Structure 12:583-592, 2004.

All cells need a chemical called asparagine to stay alive. Normal cells can make this chemical for themselves, while cancer cells cannot. Asparaginase breaks down asparagine in the body. Since the cancer cells cannot make more asparagine, they die.

What do you not get about 7 different pathways? For example, an easy way for cancer to get around this is the Lurker Pathway.

Are you refering to this ZEBRA thingy???

http://www.sciencedaily.com/releases/2006/...60220101811.htm

or how about...Curcumin???

"Curcumin stops angiogenesis

http://www.goodhealth.nu/News_Articles/050...i-cancer-US.htm

"All of the above actions of curcumin stop cancer before it has a chance to become detectable. If cancer grows to the point that it is a detectable tumor, curcumin can still have an effect.

Certain enzymes enable tumors to create a blood supply for themselves. Known as "angiogenesis," this phenomenon allows tumors to invade surrounding tissue and spread. Working with blood vessels of the eye (where angiogenesis creates big problems for vision), researchers at Tufts University were able to inhibit blood vessel formation by using curcuminoids. Curcumin blocks AP-1, which enhances angiogenesis.

Curcumin may also inhibit angiogenesis by chelating metals used by enzymes that promote the growth of blood vessels. Some of the enzymes that promote angiogenesis are known as "metalloproteinases." Metalloproteinases require metals to work. Curcumin chelates iron and probably copper-both of which help metalloproteinases create new blood vessels for tumors. In a study on a highly invasive form of human liver cancer, curcumin inhibited metastasis 70% by suppressing metalloproteinase-9. Curcumin appears to be very protective against liver cancer. In a more recent study, the incidence of liver cancer was slashed 62%, with the number of tumors decreasing by 81% in mice given curcumin four days before a carcinogenic chemical.



Curcumin possesses several other anti-cancer benefits that make it highly effective as a cancer preventive agent against almost any type of cancer. One of its most talked-about features is its antioxidant action.

The cancer preventive effects of curcumin are powerful and proven. Curcumin interferes with the ability of estrogen-mimicking and other chemicals to do damage (a trait it shares with I3C). It is a powerful antioxidant that can alter gene expression, stop the cell cycle, and induce the self-destruction of cancer cells without affecting healthy ones. By blocking signals known as kinases, curcumin interrupts signals that enable cancer cells to grow. In addition, curcumin enhances immunity and blocks the invasion and metastases of tumors. Curcumin significantly reduces the risk of cancer after chemical exposure, and appears especially beneficial against colon and liver cancers. The actions of curcumin have been the subject of presentations at major meetings on cancer research, and the object of study by researchers at the most prestigious universities in the world. If curcumin were a drug, it would be hailed as one of the best all-around cancer drugs ever invented. As it is, it's a phytochemical with impeccable credentials, thousands of years of use behind it, and a very small price tag. No wonder a host of drug companies want to imitate it."


http://www.lef.org/magazine/mag2002/jul200...urcumin_01.html

Curcumin has been found to suppress NF-kappaB activation providing beneficial effect by killing and preventing tumor growth as well as inhibiting metastatic progression



http://www.jeancarper.com/newsflash/1590

"f the mice given curcumin, very few developed metastatic tumors in their lungs. In contrast, 96% of mice not given curcumin had metastatic lung cancers. Further, curcumin not only stopped progression of the cancer, but also neutralized cancer spread that may occur after long term use of the chemotherapeutic drug Taxol.

Bharat Aggarwal, Ph.D., head investigator and professor of cancer medicine at MD Anderson, calls the results "exciting" and says they have implications for the treatment of advanced breast cancer after surgery, chemotherapy and radiation. Currently, there is no long term effective therapy for metastatic breast cancer, he says.

Curcumin works by shutting down a powerful protein known as nuclear factor-Kappa B (NF-kB), that triggers an inflammatory response needed for breast cancer to spread. When the protein is suppressed by curcumin, cancer cells cannot grow and instead commit suicide. (Source: Aggarwal BB ,Clin Cancer Res 2005;11(20): 7490-8)

In other research, Aggarwal has shown that curcumin similarly blocks the spread of lung cancer. and possibly other cancers related to cigarette smoke. Curcumin has even blocked the ability of cigarette smoke to initiate cancer in cells. Thus, curcumin may not only stop cancer spread but help prevent its occurrence. '

Angiogenesis can be caused by many sources.

Nf-kB is also only vital in MCF1 cell lines of Breast Cancer.

Are you only allowed to use 'Pubmed approved' products for your research????

No, but published work will show up on PubMed. It would be nice for this company to publish their work, instead of going on hearsay.

http://www.fimdefelice.org/

:
"FIM, The Foundation for Innovation in Medicine, was established in 1976 by Stephen L. DeFelice, M.D. It is a nonprofit foundation whose purpose is to accelerate medical discovery by creating a more productive clinical research community.

The cost and risk to conduct clinical research, the critical step in medical discovery, are major factors that retard the availability of new therapies that can eliminate or ameliorate those conditions which ail us.

FIM has asked patients (by the way, we are all patients) the fundamental question, "Who represents you?" or "What do you want?" Their responses are summarized as follows: "If I have a disease, get rid of it", or "If I don't have a disease, I don't want to get it." In medical terms these responses deal with the treatment and prevention of disease, respectively.

In order to fulfill the patients' wishes, we must have more clinical research, a critical step in medical discovery, conducted on potential new therapies so that new medical discoveries are made at a more rapid pace.

Medical technology is exploding but only a small amount of it is being clinically tested to determine its medical value.

In FIM's experience, there is little interest or appreciation of the critical importance of clinical research, and one of our primary goals is to deliver this important message.

FIM is now involved in two initiatives, all of which deal with stimulating our clinical research system.

THE NREA or NUTRACEUTICAL RESEARCH AND EDUCATION ACT: A nutraceutical is a food, dietary supplement or medical food that has a medical - health benefit including the prevention and treatment of disease. Dr. DeFelice coined the term in 1989, and it is now in Webster's Collegiate Dictionary.

Very little clinical research is conducted on specific nutraceutical products sold (far less than 1/2 per cent) mainly because of economic reasons. The potential medical or health values of these products are, therefore, largely unproven. As a result, patients and health care professionals are deprived of knowing the truth about the benefit and the safety of the products being taken.

Dr. DeFelice proposed the NREA which is based on the principles of the successful Orphan Drug Act. If a company conducts the clinical research on a specific product, it alone will have the exclusive right to make the medical claim regarding its efficacy. This marketing incentive, as happened with orphan drugs, will spur companies to invest in the clinical research necessary to demonstrate the safety and effectiveness of the nutraceuticals sold.

Congressman Frank Pallone (D-NJ) introduced the NREA in Congress in 1999 but there was little interest from any segment of the health sector. However, FIM is continuing to pursue the NREA effort.

THE PHYSICIAN VOLUNTEER or DOCTORNAUT ACT: Over a quarter of a century ago, Dr. DeFelice proposed the establishment of physician volunteers for clinical research or "doctornauts" (another term coined by Dr. DeFelice) who would have the right to volunteer for clinical research much more freely than normal volunteers. This would reduce the enormous barriers, costs and risks to participate in a clinical study. Once established, many more potential medical therapies will be tested and medical discovery dramatically accelerated which is, to repeat, what patients want.

FIM is currently in the process of establishing the consensus among various institutions and organizations to educate the Congress about the urgency to pass the Doctornaut Act.


Announcements

The October 2006 DeFelice Commentary
Medical Versus Scientific Clinical Research:
Time for an Immediate Change!
Go to DeFelice Commentary.

Dr. DeFelice's new novel "He Made Them Young Again" See the listing.

Westfield's Dr. DeFelice Answers the 'Age Old Question'. See article

Announcement -The Doctornaut Act, a Proposal by FIM

In his first book, Drug Discovery the Pending Crisis, published in 1972, Dr. DeFelice proposed that, as a way to accelerate medical discovery, physicians should be permitted to volunteer for clinical research studies with significantly fewer restraints, including taking greater risks than non-physician volunteers. Later on, he coined the term "Doctornaut" to describe such physician volunteers. Because of the highly promising medical potential of modern technology, FIM has proposed that Congress pass the Doctornaut Act. Read the Doctornaut Act or the summary article in the September issue of Exceptional Parent magazine. "

To make this happen it is critical that Congress hear from you regarding your support of this Act. We urge that you contact Dr. Bill Frist at http://frist.senate.gov, one of only two physicians in the Senate, who has as one of his primary goals, "To speed up new medical therapies from the bench of laboratory scientists to the bedside of patients." Also, it's important that you contact your local congressional representatives and senators. You can access your local information from the home page of our FIM website http://www.fimdefelice.org or go directly to both http://www.congress.org or http://www.Senate.gov.

An article appeared in the Westfield Leader and The Times about the Doctornaut Act. It can be read in our news clippings section. Read.

A Special Message for Parents of Children with Disabilities and Disease: Doctornauts Can Help Your Child! Read.

THE FOUNDATION FOR INNOVATION IN MEDICINE

411 North Avenue East
Cranford, New Jersey 07016
(908) 272-2967 Fax: (908) 272-4583
E-mail: fimdefelice@aol.com



http://medicine.plosjournals.org/perlserv/...al.pmed.0020124

And?

?????????????

"
THE NREA or NUTRACEUTICAL RESEARCH AND EDUCATION ACT: A nutraceutical is a food, dietary supplement or medical food that has a medical - health benefit including the prevention and treatment of disease. Dr. DeFelice coined the term in 1989, and it is now in Webster's Collegiate Dictionary.

Very little clinical research is conducted on specific nutraceutical products sold (far less than 1/2 per cent) mainly because of economic reasons. The potential medical or health values of these products are, therefore, largely unproven. As a result, patients and health care professionals are deprived of knowing the truth about the benefit and the safety of the products being taken.

Dr. DeFelice proposed the NREA which is based on the principles of the successful Orphan Drug Act. If a company conducts the clinical research on a specific product, it alone will have the exclusive right to make the medical claim regarding its efficacy. This marketing incentive, as happened with orphan drugs, will spur companies to invest in the clinical research necessary to demonstrate the safety and effectiveness of the nutraceuticals sold."

It would be nice if a doctor could suggest food groups and lifestyle changes that would assist in healing as well as prescribing medications...

but I gather there may be rules and regulations against this...

If you haven't noticed...they do. Especially Pediatricians.


Yet something that could prevent cancer must be researched. Until then, I think cookies prevent cancer

I must have seen some of the wrong doctors... often the ones I see spend a couple of minutes listening... may check the ears ..eyes..mouth...blood preasure or temp... then they look thru a couple of books??? or on line...and prescrible something...usually some sort of penicillin...or if that doesn't work.. a couple of blood tests...usually time spent with the doctor is less than 5 minutes... even when the waiting room is nearly empty!!!


LOL Where's 'House' when you need him???...

http://www.imdb.com/title/tt0412142/
. but then again ..he nearly kills his patients before he finds a cure or the cause....

It makes for a good TV drama.

Basically what I'm trying to achieve here ..what we should be doing is trying to provide . information.. hope...for all the extended families and sufferers of various cancers.... allow them to retain some power over their own lives... with natural choices...that could assist in their healing...information for their families...because naturally they too would wonder if they or other family members may be next!!!

What healthy lifestyle choices could they make??? what could they include in their diet or life style choices to prevent similar cancers... give them something pro-active... not just place their lives in the hands of their oncologists....

If the patients and families also know that they can do something... the will...the knowing of possibilities...other complementary options other histories/cases..will help a lot towards their recovery...and their frame of mind...

When my father and some of my friends got cancer they were more or less told .. it was oncology treatments or nothing...so they didn't even look to see if there was anything else that they could do... and were full of fear the whole time!!! as were the families!!!

As the possibilities of catching a form of cancer increases every year... it is something that we should really investigate...

And devise a huge support framework for all those emotionally bleeding people of now and the future...

You can't "catch" cancer. You develop it due to exposure of genetics.


That's because chemotherapy and other treatments are MUCH more effective than many natural remedies.


It's wise to trust your oncologist.

http://www.cancure.org/choiceoftherapy.htm

It depends on the type..

Trust your Oncologist!

" http://www.oralcancerfoundation.org/news/news.asp?offset=180
They discovered that the kind of bacteria living in the throats of people with a disease called Barrett's Oesophagus, which increases the risk of cancer by up to 125 times, was significantly different from the "flora" found in healthy people.

Those with the disease were found to have one particular kind of bacteria, an unusual form of campylobacter, which has been linked with cancer of the oesophagus in animals.

The researchers now plan to investigate whether the use of probiotics, prebiotics or a combination of the two called synbiotics can change the make-up of the bacteria and prevent the genetic damage that results in cancer.

Cancer deaths resulting from Barrett's Oesophagus have been increasing in Europe over the last three decades and in the UK it has risen from the 20th most common type of cancer death to the seventh most common."

http://intelegen.com/ImmuneSystem/garlic_berberine.htm

"The Ideal Antibiotic
The ideal antibiotic should not only kill bacteria, it should also promote optimal immune function. Effective as today?s pharmaceutical antibiotics are ?in extreme cases, they can be lifesaving?they do only part of the job. Because inadequate dosing and inconsistent use of these drugs is a major cause of antibiotic resistance, they are appropriate only for treating ongoing infections. They cannot and should not be used for preventing disease on a chronic basis. Furthermore, antibiotics kill only bacteria, and are useless against infections caused by viruses, fungi, parasites, and worms.

An alternative, and in many cases preferable choice is a combination of natural antibiotics, combined with various immune stimulants.

VRP?s new UniBiotic? is a specialty formula which synergistically combines berberine, garlic, echinacea, and spleen extract to support natural immune response and to directly attack infectious organisms. UniBiotic is effective not only against many bacteria, but also against many protozoa, worms, and fungi.

Berberine
Herbs containing berberis alkaloids, including hydrastis canadensis, Berberis vulgaris, and Berberis acquifolium (Oregon grape) have a long history in folk medicine. Native Americans used hydrastis and Oregon grape to soothe inflamed tissues in cases of respiratory, digestive, or genitourinary conditions related to allergy or infection, as well as skin conditions, such as acne, psoriasis, and eczema. In European, Asian, and North African folk medicine traditions, Berberis vulgaris was used to treat diarrhea and fevers and to prevent hemorrhage.

In laboratory studies, berberine, the most important of the berberis alkaloids, has been shown to have antibiotic, immunostimulatory, anticonvulsant, sedative, and hypotensive (blood pressure-lowering) activity, among other effects. Of these, its antibiotic effects have aroused the most interest.

Although not as potent as many prescription antibiotics, berberine exhibits a broad spectrum of antibiotic activity that includes a variety of bacteria, protozoa, and fungi. Among the bacteria that are vulnerable to berberine are Staphylococcal, Streptococcal, and Enterococcal species. Berberine also inhibits the growth of yeasts, such as Candida, which often overgrow and cause a secondary infection after ordinary antibiotic treatment. Not only does berberine kill bacteria, it also helps boost immunity, in part by increasing the blood supply to the spleen and by activating macrophages.

Berberine is used clinically to treat acute diarrhea caused by a variety of pathogenic bacteria, including E. coli, Klebsiella, Giardia lamblia, and Vibrio cholerae. It can be used to great advantage prophylactically when traveling in areas with poor water quality.

Garlic
During a widespread plague in early 18th century Marseilles, France, four condemned criminals recruited to bury the dead were noted to be immune to the deadly infection. What was their secret? They had been drinking a concoction of garlic soaked in wine that came to be known as vinaigre des quatre voleurs (four thieves? vinegar) and is still available in France.

Garlic as a means of warding off infection and other medical uses has been practiced since the dawn of civilization. Records of its use date back more than 5,000 years in India, 3,000 years in China, and 1500 years in Egypt.

Garlic and its active ingredient allicin have broad-spectrum activity against many types of bacteria, viruses, worms, and fungi. Low doses of garlic are particularly lethal to such bacteria species as Staphylococcus, Streptococcus, Brucella, Vibrio, Salmonella, and many others. Some studies have shown that garlic can inhibit the growth of bacteria that have developed resistance to one or more conventional antibiotic drugs. In addition to its bactericidal effects, garlic has also been shown to boost immune function.

Garlic?s antimicrobial activity was noted by Pasteur in 19th century France and used by Dr. Albert Schweitzer to treat amoebic dysentery in Africa earlier in this century. It was also used as an antiseptic for preventing gangrene during World Wars I and II.

Echinacea
Echinacea is one of the most popular natural herbal remedies in common use today. It is used especially for preventing or treating common infections, such as colds, flu, and urogenital infections.

Like berberine and garlic, Echinacea has its roots deeply imbedded in folk medicine. Echinacea is derived from nine major species of perennial herbs that are native to northwestern North American, in a band stretching from Texas to Saskatchewan. It was used by Native Americans to treat more illnesses than any other plant. Among its most common uses were to promote healing of wounds, burns, abscesses, insect bites, internal infections, toothaches, and joint pains. It was also used as an antidote for rattlesnake bites. Around 1870, commercial medicines containing Echinacea began to appear and became popular with many physicians as a local anesthetic, stimulant, deodorant, and as a treatment for internal infection and malignancies. During the 1930s, German researchers demonstrated that extracts of certain Echinacea species had
immune-enhancing properties.

The important pharmacologic constituents of Echinacea include polysaccharides, flavonoids, caffeic acid derivatives, essential oils, polyacetylenes, alkylamides, and various miscellaneous chemicals. These factors contribute to the herb?s ability to promote tissue regeneration, reduce inflammation, and stimulate immune function. Its diverse immuno-modulatory activities include promotion of movement of white blood cells (neutrophils, monocytes, and eosinophils), solubilization of immune complexes, neutralization of viruses, activation of T cells, production of interferon, and secretion of lymphokines. These actions result in enhanced macrophage phagocytosis, antibody binding, natural killer cell activity, and increased numbers of T cells and polymorphonuclear neutrophils (PMNs). "

An Anitbiotic can't do everything. NOTHING can do everything. That's why we DO have seperate treatements for cancer, fungus, parasites, etc.

It seem that natural antibiotics/fungicides are more broad range than the lab created bacterial ..viral.. specific brands... with fewer less toxic side affects??

You yourself said that it was bacteria..etc... that caused mutations of genes...cells... and isn't that ( if the body's immune system is out of whack..or hasn't the resources..eg the nutritional larder... to combat it) when diseases or cancers accur???

Just off topic ???

Saw this site....

http://www.abc.net.au/rn/scienceshow/stori...006/1590330.htm

"Robyn Williams: We heard from Rainer Maier last week talking about the Atacama Desert and new life forms. This time it's on the kind of lucky break you sometimes get in science, which could be worth billions.

Raina Maier: Well, that came about by accident, and it was one of the most exciting discoveries of my career just because it happened by accident. A colleague was walking into work with Mike Stanghellini who was Professor of Plant Pathology, and Mike was telling my colleague that one of his greenhouse experiments hadn't worked. So they had a control where they infected the plant with the fungicide and the plant died and then all the rest of the plants on the same hydroponic system should get infected and die as well, but they didn't. So the inoculated one died but the rest were fine, and when they looked in the hydroponic tub they saw a lot of foaming. So my colleague said to Mike, 'You need to talk to Raina because she works with biosurfactants', which are microbial detergents. And so, indeed, Mike came to see me and we talked for a little while and he said, 'You know, I've plated some microbes from the tub and they look like they're Pseudomonas.' I said, 'Mike, I know exactly what you have. I've been working with this stuff for six, seven years now. It's called rhamnolipid.' And we gave Mike some purified rhamnolipid and he tested it against the plant pathogens, and indeed it's a very effective fungicide. We went on to publish this and actually get a patent for the use of this."


...as the article was dated April 1st... and the interviewer was Robyn Williams... I thought it could be a Scientific hoax... but it appears it's for real !!!!

http://jac.oxfordjournals.org/cgi/content/abstract/57/4/609
Biosurfactants: potential applications in medicine

Some bacteria or toxins may cause mutations, other mutations just occur, like the TMPRss2/ERG fusion.

or added hormones to our food chain.....

"Furthermore, the accumulating evidence confirmed the mutagenic and
genotoxic potential of 17 â oestradiol. The complex biotransformation of
trenbolone, zeranol and melengestrol acetate was identified.
Experimental and epidemiological data were evaluated regarding possible
consequences for the incidence of cancer from pre- and perinatal
exposure to hormones."

http://www.organicconsumers.org/toxic/hormone042302.cfm

This too is interesting... findings and studies of nearly a century ago!!!!




http://www.dr-gonzalez.com/clinical_pearls.htm


Scottish embryologist, John Beard, who worked at the University of Edinburgh at the turn of the century, first proposed in 1906 that pancreatic proteolytic enzymes, in addition to their well-known digestive function, represent the body’s main defense against cancer. He further proposed that pancreatic enzymes would most likely be useful as a cancer treatment.........


"On the other hand, patients with the blood or immune based malignancies such as leukemia, myeloma and lymphoma do best on a high-animal protein, high-fat diet. Such patients do extremely well with a diet based on animal products with minimal to moderate amounts of plant based foods, the particular design of the diet again depending on the individual patient’s metabolic make-up.......

We find patients with pancreatic cancer always do best with a largely plant-based diet that emphasizes fruits, vegetables and vegetable juice, nuts, seeds and whole grains. Allowed protein includes fish one to two times a week, one to two eggs daily and yogurt daily, but no other animal protein. In our therapy, we use diets specifically because of the effect of food on the autonomic nervous system. This system consists of the sympathetic and parasympathetic branches and ultimately controls all aspects of our physiology, including immune function, cardiovascular activity, endocrine function and the entire action of our digestive system. The sympathetic and parasympathetic systems have opposing actions on the target organs and so can adjust our physiology depending on needs and demands, enabling our bodies to react to any situation, condition or stress. We believe disease, whatever the form, occurs because there is an imbalance in autonomic function. For example, we find solid tumors, such as tumors of the breast, lung, pancreas, colon, uterus, ovaries, liver, etc occur only in patients who have an overly strong sympathetic nervous system and a correspondingly weak, ineffective parasympathetic nervous system. We believe that blood-based cancers, such as leukemia, lymphoma and multiple myeloma, only occur in patients that have an overly developed parasympathetic nervous system, and a correspondingly weak sympathetic nervous system. Previous research, such as Dr. Francis Pottenger’s research during the 1920s and 1930s proposed that much if not all disease has autonomic imbalance as at least one of the major causes.

We have found that specific nutrients and foods have specific, precise and predictable effects on the autonomic nervous system. For example, a vegetarian diet emphasizes fresh fruits and vegetables, particularly leafy greens, and contains large doses of minerals such as magnesium and potassium. It has been shown in many studies that magnesium suppresses sympathetic function, while potassium stimulates parasympathetic activity. Furthermore, a largely vegetarian diet tends to be very alkalinizing, and the neurophysiologic research documents that in an alkalinizing environment, sympathetic activity is reduced and parasympathetic activity increased. So, whatever other effect a vegetarian diet has, in terms of autonomic nervous system function, such a diet will reduce sympathetic activity and stimulate the parasympathetic system.

A meat diet is loaded with minerals such as phosphorous and zinc, which tend to have the opposite effect. A high-meat diet stimulates the sympathetic system and tones down parasympathetic activity. Furthermore, such a diet is loaded with sulfates and phosphates that in the body are quickly converted into free acid, that in turn stimulates the sympathetic nervous system while suppressing parasympathetic activity.

So, by the careful use of diet, we are able to effect major changes in autonomic function, and bring about balance in a dysfunctional nervous system. We find, further, as the autonomic system comes into greater harmony and balance, when the autonomic branches are equally strong, all systems – from the immune system to the cardiovascular system – work better regardless of the underlying problem. In essence, we are using diet to bring about greater physiological efficiency. For cancer patients, long experience has taught us that it is not enough to load patients with enzymes; the question of autonomic imbalance must also be addressed. In terms of pancreatic patients specifically, a plant-based diet provides all the nutrients to correct autonomic dysfunction."

http://www.life.ca/nl/61/melatonin.html

Melatonin, a naturally-occurring hormone that regulates the body clock, has been identified in significant levels in several popular herbal treatments by researchers at the University of Guelph.

Melatonin is popular as a natural treatment for ailments like migraine headaches, insomnia and gastrointestinal illnesses. It is produced by the pineal gland, a tiny organ at the centre of the brain; its secretions occur primarily at night and are associated with the onset of sleep.

The effect of the newly-discovered plant-based melatonin is not scientifically understood but its presence may be useful for identifying plants with medical potential, says University of Guelph horticultural professor Praveen Saxena, who led the team that made the discovery.

The amount of melatonin in some of the samples tested higher than commercial preparations currently sold in health food stores in the United States. Melatonin can not be legally sold in Canada, but an informal survey of health food stores in southern Ontario revealed that it is readily available.

Researchers in Saxena’s laboratory found relatively high levels of melatonin in the leaves of feverfew (Tanacetum parthenium), a herb used to treat migraine headaches; the flowers of St. John’s Wort (Hypericum performatum), a herb used as an anti-depressant and tranquillizer; in the Chinese herb Hunag-quin and in commercial preparations of feverfew leaves.

Additionally, melatonin has other means to lower the damage resulting from inflammation. Thus, it prevents the translocation of nuclear factor-kappa B (NF-{kappa} to the nucleus and its binding to DNA, thereby reducing the upregulation of a variety of proinflammatory cytokines, for example, interleukins and tumor neurosis factor-alpha. Finally, there is indirect evidence that melatonin inhibits the production of adhesion molecules that promote the sticking of leukocytes to endothelial cells. By this means melatonin attenuates transendothelial cell migration and edema, which contribute to tissue damage.

http://www.annalsnyas.org/cgi/content/abstract/917/1/376