http://www.twnside.org.sg/title/late-cn.htm
Review of Norwegian Report to the Directorate of Nature Management, Norway
" Emphasis is placed on the fact that the vectors used in genetic manipulation are constructed from genetic parasites (viruses, plasmids, mobile elements) which are developed to express genes across species boundaries and ecological barriers. Many of them are able to invade and insert their DNA into the chromosomes of any kind of cell and they are specially constructed to break species barriers. They may in transit have the ability to pick up and transfer genes from new host organisms or other genetic parasites therein. Pathogenic viruses may result with potential to infect earlier refractory hosts and during such potential relays, genetic rearrangements and mutations may arise with unpredictable results. Most vectors also carry antibiotic resistance as markers for integration, these genes also have the potential to leak.
* The belief that DNA in food and forage cannot be up-taken from the gastrointestinal tract is considered to be a dogma by this report. Recent research demonstrated that following ingestion by mice, DNA from the M13 bacteriophage could be detected as relatively long fragments in faeces, peripheral leukocytes, spleen and liver cells in significant time intervals after feeding. In cells the ingested M13 DNA was found in a chromosome integrated form (Doerfler et al,. 1997; Schubbert et al,. 1997). When such DNA was fed to pregnant mice it was detected in various organs from foetuses and newborn animals ( Doerfler and Schubbert 1998).
All these factors add up to a real possibility of genetic pollution via cross-pollination, unplanned breeding and horizontal gene transfer. The level of naked DNA persistence in the environment is likely to increase the chances of such pollution occurring and the report suggests that extensive unpredictable health, environmental and socioeconomic problems may result.
This report questions whether the development of GMO deserves the label "technology". Technology is associated with predictability, control and reproducibility yet the GM of cells and organisms means no possibility to target specific genomic sites, no control over the changes in gene expression patterns for the inserted gene and the endogenous genes of the GMO and no control over the fate of the transgene or parts of the transgene once in situ and once released into an ecosystem.
The report claims that there has been a lack of competent, independent expertise in many technological fields and goes on to document examples of accidents and erroneous evaluations where the full extent of ecological damage largely remains unknown. e.g. the mis-use of antibiotics and the spread of antibiotic resistance, the emergence of recombinant viruses within transgenic plants engineered to be resistant to viruses (Green & Allison, 1994), the laboratory escape of the hybrid "African killer Bees" which resulted in the deaths of more than 1000 people and the BSE/ nvCJD episode in Britain."