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crystal sage

Alprim .. Septrim..Trimethoprim..Bactrim

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crystal sage

:mellow: Is it safe????

Septrin - Bactrim - Septra - Sulfatrim: grass roots campaign over side-effects

grass roots campaign over side-effects

This page is from a collection of materials indexed at this website arising from an investigation and campaign by Brian Deer in The Sunday Times of London over serious risks and side-effects from this antibiotic, marketed under many names, including Bactrim, Bactrim DS, Septra, Septra DS, Septrin, Sulfatrim, SMZ/TMP, Septran and co-trimoxazole. Go to side-effects homepage

Following the first UK media reports in 1994 about the risks of Septrin - Bactrim - Septra - Sulfatrim, many people said they had suffered side-effects and wanted to be put in touch with others. Zofia Mescall was an early mover, who quickly formed this group, focussed primarily on victim support, media coverage and pressing for government action to restrict the drug

http://briandeer.com/septrin/bactrim-victims.htm

http://www.taumed.com/content/adam/browse....&cid=128600

Contraindications Back to top

Hypersensitivity to trimethoprim or any component of the formulation; megaloblastic anemia due to folate deficiency

Adverse Reactions Back to top

Frequency not defined.

Central nervous system: Aseptic meningitis (rare), fever

Dermatologic: Maculopapular rash (3% to 7% at 200 mg/day; incidence higher with larger daily doses), erythema multiforme (rare), exfoliative dermatitis (rare), pruritus (common), phototoxic skin eruptions, Stevens-Johnson syndrome (rare), toxic epidermal necrolysis (rare)

Endocrine & metabolic: Hyperkalemia, hyponatremia

Gastrointestinal: Epigastric distress, glossitis, nausea, vomiting

Hematologic: Leukopenia, megaloblastic anemia, methemoglobinemia, neutropenia, thrombocytopenia

Hepatic: Liver enzyme elevation, cholestatic jaundice (rare)

Renal: BUN and creatinine increased

Miscellaneous: Anaphylaxis, hypersensitivity reactions

Overdosage/Toxicology Back to top

Symptoms of acute toxicity include nausea, vomiting, confusion, and dizziness. Chronic overdose results in bone marrow suppression. Treatment of acute overdose is supportive following GI decontamination. Use oral leucovorin 5-15 mg/day for treatment of chronic overdose. Hemodialysis is only moderately effective in eliminating drug.

Drug Interactions Back to top

Substrate (major) of CYP2C8/9, 3A4; Inhibits CYP2C8/9 (moderate)

ACE inhibitors: Concurrent therapy increases the risk of hyperkalemia.

CYP2C8/9 inducers: May decrease the levels/effects of trimethoprim. Example inducers include carbamazepine, phenobarbital, phenytoin, rifampin, rifapentine, and secobarbital.

CYP2C8/9 substrates: Trimethoprim may increase the levels/effects of CYP2C8/9 substrates. Example substrates include amiodarone, fluoxetine, glimepiride, glipizide, nateglinide, phenytoin, pioglitazone, rosiglitazone, sertraline, and warfarin.

CYP3A4 inducers: CYP3A4 inducers may decrease the levels/effects of trimethoprim. Example inducers include aminoglutethimide, carbamazepine, nafcillin, nevirapine, phenobarbital, phenytoin, and rifamycins.

Dapsone: Trimethoprim may increase dapsone concentration/toxicity.

Digoxin: Trimethoprim may increase digoxin concentrations.

Methotrexate: Trimethoprim may increase methotrexate toxicity.

Phenytoin: Trimethoprim may increase phenytoin concentration/toxicity.

Procainamide: Trimethoprim may increase procainamide concentrations.

Stability Back to top

Protect the 200 mg tablet from light.

Mechanism of Action Back to top

Inhibits folic acid reduction to tetrahydrofolate, and thereby inhibits microbial growth

Pharmacodynamics/Kinetics Back to top

Absorption: Readily and extensive

Distribution: Widely into body tissues and fluids (middle ear, prostate, bile, aqueous humor, CSF); crosses placenta; enters breast milk

Protein binding: 42% to 46%

Metabolism: Partially hepatic

Half-life elimination: 8-14 hours; prolonged with renal impairment

Time to peak, serum: 1-4 hours

Excretion: Urine (60% to 80%) as unchanged drug

http://www.askapatient.com/viewrating.asp?...mp;name=BACTRIM

here are 313 ratings for the drug: bactrim in the Askapatient database.

So what they may forget to tell you is that if you are on large doses... eg for Acne... where you take 2 tablets a day for months... you should have your blood work done every 2 weeks to ensure no serious side effects...especially if you are getting severe headaches and stomach aches...whilst on this....

Edited by crystal sage

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Fluffybunny

Every single medication has side effects. Heck even the homeopathic "cures" have side effects. what is your point?

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Fluffybunny

Is this something that you are worried about taking? just a random post? I dont quite understand...

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crystal sage

http://briandeer.com/septrin/bactrim-effects-26.htm

ME & Septrin

http://www.investinme.org/InfoCentre-vaccines-popup-3.htm

http://ummafrapp.de/skandal/The%20Perversi...S-Medicine2.pdf

http://www.appgonline.com.au/drug.asp?drug...00209&t=cmi

If you are taking Alprim for a long time, visit your doctor regularly so that they can check on your progress.

You may need to have regular blood tests.

Edited by crystal sage

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crystal sage
For the professional

http://www.drugs.com/sfx/sulfamethoxazole-...de-effects.html

Sulfamethoxazole and Trimethoprim

The most common adverse effects are gastrointestinal disturbances (nausea, vomiting, anorexia) and allergic skin reactions (such as rash and urticaria). FATALITIES ASSOCIATED WITH THE ADMINISTRATION OF SULFONAMIDES, ALTHOUGH RARE, HAVE OCCURRED DUE TO SEVERE REACTIONS, INCLUDING STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, FULMINANT HEPATIC NECROSIS, AGRANULOCYTOSIS, APLASTIC ANEMIA AND OTHER BLOOD DYSCRASIAS.

Hematologic

Agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, neutropenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia.

Allergic Reactions

Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, drug fever, chills, Henoch-Schoenlein purpura, serum sickness-like syndrome, generalized allergic reactions, generalized skin eruptions, photosensitivity, conjunctival and scleral injection, pruritus, urticaria and rash. In addition, periarteritis nodosa and systemic lupus erythematosus have been reported.

Gastrointestinal

Hepatitis (including cholestatic jaundice and hepatic necrosis), elevation of serum transaminase and bilirubin, pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhea, anorexia.

Genitourinary

Renal failure, interstitial nephritis, BUN and serum creatinine elevation, toxic nephrosis with oliguria and anuria, crystalluria and nephrotoxicity in association with cyclosporine.

Metabolic and Nutritional

Hyperkalemia).

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Fluffybunny

Have you ever read through a PDR?

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crystal sage
Is this something that you are worried about taking? just a random post? I dont quite understand...

Was just wondering if anyone here at the forum had any concerns with the drug... According to our doctors..skins specialists... Alprim is the safest drug going... even used for cancer patients....

However it doesn't seem to be the case... If it suppresses the bone marrow... white blood cells... how can it be good for immune deficient patient... eg cancer patients????

Won't it just weaken them????

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Fluffybunny

Well, no one here is going to have anymore information than a PDR or any other online drug guide; no one here is a specialist or qualified to give advice in that area...you know what I mean?

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Fluffybunny

Yes, PDR gives a good deal of info on drug interactions...

It is a case by case situation and very very dificult to say whether it is appropriate or not for a person. It may be for one person, and not for another...it takes the medical team and the patient to figure out what is best given the situation.

Side effects are simply a part of every medication, it is impossible to have a medication that is side effect free. In the case of antibiotics the body can react pretty severely, but often they are very needed. There may be options of antibiotics, but you cant exactly not take them if there is an infection...you need to deal with them. If you are dealing with cancer and an already damaged immune system it is even more critical to take care of infections...

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crystal sage

But taking something that further suppresses/damages the immune system would not be wise.. would it????

eg nature inspired sources... eg Berberine...

with fewer if any side effects....

http://meded.ucsd.edu/isp/2003/thomas/herb_goldenseal.html

http://www.planetherbs.com/articles/cancer.html

http://www.cancersalves.com/botanical_appr...nce_elixir.html

http://mct.aacrjournals.org/cgi/content/abstract/5/2/296

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Fluffybunny

One of the things that you need to keep in mind is how effective that homeopathic meds actually are...for example, the first thing you listed was berberine, which claims to have antibiotic properties; well it does...not very good antibiotic qualities, nowhere near what good old penicillin might have, nothing that is going to treat a person who has infections that already has a compromised immune system. It isnt going to be helpful and there are so many other options available that are very effective, and tested and safe.

A lot of things have antibiotic qualities; it doesnt mean that they are antibiotics...the ancient egyptians used honey on open wounds for its antibiotic qualities, something that has some degree of merit, but we have moved on and found better things to use.

There are a lot of different kinds of medications to use; thousands...each of them having benefits and side effects and interactions with each other. Each person will react differently with each medication so it is rally important that the doctor and the patient work closely to make sure that the right result is being achieved. If something is going wrong with a med, then there are other options, but taking things like berberine and expecting any kind of result like an actual antibiotic is just a mistake and I would hate to see that; it would just end in a runaway infection.

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crystal sage

http://www.healyprozac.com/

‘All policymakers must be vigilant to the possibility of research data being manipulated by corporate bodies and of scientific colleagues being seduced by the material charms of industry. Trust is no defence against an aggressively deceptive corporate sector.’ — Editorial (2000). Resisting smoke and spin. Lancet 355, 1197.

http://briandeer.com/septrin/bactrim-effects-7.htm

| brian deer | BACTRIM - SEPTRA: A SECRET EPIDEMIC

http://briandeer.com/septrin/bactrim-effects-1.htm

Septrin - Septra - Bactrim - Sulfatrim: mail to this site on side-effects (1)

This page is from a collection of materials indexed at this website arising from an investigation and campaign by Brian Deer in The Sunday Times of London over serious risks and side-effects from this antibiotic, marketed under many names, including Bactrim, Bactrim DS, Septra, Septra DS, Septrin, Sulfatrim, SMZ/TMP, Septran and co-trimoxazole. Go to side-effects homepage

Below is page 1 of a selection of mail to this website. If you want to read of bad experiences, start with selected letters to The Sunday Times at this link. Most users have no problems, but feel free to share your own experience, which may help others. Please note that Brian Deer is a journalist and that this site has many visitors. He finds it quite difficult to keep on top of detailed questions

SEPTRA DS: 2 November 2002

Mr. Deer,

I am a 28 year old female who has never had any serious health problems in my life. I recently took Septra DS for a urinary tract infection because I am deathly allergic to almost all other antibiotics on the market. It has been about a week and a half since I finished the medication and I have been having some fluttering in my chest and chest pains. It seems as if my heart is not beating regularly and I am very weak a lot of the time. I do not seem to have the energy I used to. I am the mother of three children under the age of 4 and I know that makes me tired also but it is all I can do to keep up with them, much less laundry and housekeeping. I recently had an echocardiogram, ekg, holter monitor, and bloodwork done at my internists office to see what could be causing my problems. I just wondered-does this correlate to any of the people who wrote in to you about injuries and deaths regarding taking septra ds? Also, how long did it take for most of them to have these problems? I am frightened by what I read in your articles and would like any information you have regarding effects people had. I also have been having memory problems as I read one man say that he had. I was on the medication for a week and I never had any bad side effects while taking it-which is extremely surprising considering I am allergic to all the other drugs. I felt sure I would be to a sulphur drug. Please e-mail me with the information you have if possible. I would appreciate it. Also, I am nursing a three month old and was told that it was safe to take Septra while nursing. What is your knowledge of this also?

Thank you,

Mrs Charley M.

SEPTRIN: 6 November 2002

Brian,

As a teenager I suffered badly from acne. Around 1981 I was prescribed Septrin by my GP. This drug I took twice a day for the best part of eighteen years. At the time I suffered few side effects, other than an ocassional rash and a general ache in my lower left side. I consulted my GP (I think around 1990 time),who dismissed this as nothing to worry about.

My problem now, is that although I no longer take septrin (and have not done so since 1998) I now suffer from discomfort in bones and joints, have microheamaturia, tingling and stabbing sensations mainly around the left side/kidney area.I have consulted my GP and suggested that Septrin may have a part to play here. He said to me and I quote, 'it;s all in your mind man'. However I insisted that I be seen by somebody and was sent to a Kidney specialist(nephrologist) After having undergone numerous tests the the doctor thinks that it is unlikely that there is any serious disease of the kidney.

I am therefore still left with the dicomfort and the pains which seem to be getting worse but with nowhere to turn. Can you tell me am I alone in experiencing this, are there others I can speak with and where can I get advice on my best course of action.

Although my condition is not a bad as some that I have read about I would be grateful for any help that you could provide.

Many thanks

Peter H.

BACTRIM: 4 December 2002

Dear Mr. Deer:

I am the father of a four year old girl; her name is Ibeliza and she was diagnosed with ALL (Acute Linphoblastic Leukemia) since October-17th.

Now she is receiving chemiotherapy and BACTRIM is been used to protect her from infections due to the low levels of defenses she have. In fact, BACTRIM is part of most of the chemiotherapy protocols used worldwide in the ALL treatment.

Right now she is neuthropenic and I was reviewing information about sides effects of BACTRIM. In some web sites, I found that it causes neuthropenia and I read about several effects on the formation of blood cells.

Suddenly I found your extense information and one question come: CAN BACTRIM BE AN EXTERNAL FACTOR IN THE DEVELOPING OF ALL? This is because Ibe used this drug often, prescribed by her pediatric physician, each time she had some kind of infections (several, several times, especially when she returned each new year to school, since she was 1.5 year old.

I understand that genetic predisposition is the main cause of developing cancer buy this condition need an unknown ambiental factor.

Maybe, your research will have some kind of information in order to let us continue looking for answers.

We are from Ecuador; sorry for my English but it will be very interesting to count with your comments if I could tell you my doubts!

Regards.

Vera S. Ecuador

http://briandeer.com/septrin/bactrim-effects-1.htm

BACTRIM & SEPTRA: 7 February 2003

Mr. Deer: I work for an attorney, *** ******, in Birmingham, AL, USA. We have been extremely interested in your articles regarding Bactrim/Septra and the adverse side effects of this drug. We have a case regarding an 18 year old who had acne. His dermatologist gave him Bactrim, double strength, after 7 months without any blood work being done he developed aplastic anemia and died. We noticed that most of your information (that we have found) stopped in or around 1994. Mr. ****** would be very interested to know if you have any additional information? Or do you know of any such situations in the USA? Anyone here that is aware of these side effects? We are in the process of trying to get statistics on the number of reported deaths regarding this drug but to no avail. Lots of information on internet but nothing concrete.

If you can offer any help or give us any additional information it would be greatly appreciated.

Thanks for any help you can offer,

J.T, Birmingham, AL.

http://www.askapatient.com/viewrating.asp?...mp;name=BACTRIM

Edited by crystal sage

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