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Predicting the recombination potential of SARS-Cov-2 -- MERS-Cov and Chimeric Variants created


Manwon Lender
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Note Mortality Rates of SARS-Cov-2 and MERS-Cov

1.  MERS-Cov -- 35%

2.  SARS-Cov-2 -- 1.8 to 3.2% based upon geographical location.

3.  Recombination of a SARS-Cov-2 and MERS-Cov Chimera variant virus -- Unknown

The potential ability of SARS-CoV-2 and MERS-CoV genomes to recombine raises many concerns, including the role of accessory proteins in modulating human immune responses. MERS-CoV accessory proteins are very efficient in counteracting human innate antiviral responses by blocking interferon (IFN) production and signalling. A recent study identified that SARS-CoV-2 can inhibit antiviral IFN production; however, interestingly, downstream expression of IFN stimulated genes (ISGs) were observed in cells that were experimentally infected with SARS-CoV-2. Thus, any recombination between SARS-CoV-2 and MERS-CoV genomes may generate viruses with unpredictable pathogenic potential.

RNA recombination between SARS-CoV-2 and MERS-CoV genomes may produce chimeric proteins, which in turn may affect the efficacy of drug interactions. Thus, it is important to identify potential recombination breakpoints and develop pan-CoV drugs that are effective in inhibiting the replication of diverse CoVs.  In our analysis, we did not detect high levels of co-expression of ACE2 and DPP4 in human lung tissue; however, both SARS-CoV-2 and MERS-CoV cause respiratory infections in humans. Thus, the possibility of recombination in human lung tissue or cells within the respiratory tract cannot be ruled out. Ongoing research will shed more light on the full range of SARS-CoV-2 receptors and co-receptors, optimal levels of receptor expression required to facilitate CoV entry, and respiratory tract tissues and cell types that are susceptible to SARS-CoV-2 and MERS-CoV.

There is a need to develop ancestrally reconstructed pan-CoV bait capture assays to further expand upon the efforts of Li et al.  To capture and detect RNA from SARS-CoV-2/MERS-CoV recombinant viruses. Rapid capture and sequencing diagnostics will allow frontline diagnostic laboratories to enrich patient samples for SARS-CoV-2, MERS-CoV and any potential recombinant viruses. The bait sets can be deployed in high-risk areas to actively survey and monitor circulating SARS-CoV-2 and MERS-CoV variants or recombinants, or in response to molecular diagnosis of co-infection in individual patients. In addition, from a public health perspective, it would be strategic to separate COVID-19 and MERS patients in hospitals and perhaps have dedicated staff handling cases of each disease in high risk areas.

Both SARS-CoV-2 and MERS-CoV have demonstrated their ability for nosocomial spread. Thus, broader public health awareness is necessary to manage intake of COVID-19 patients in high-risk MERS-CoV endemic areas. While continued and serious efforts to control the ongoing COVID-19 pandemic are necessary, we must also be prepared to identify and curb the spread of any antigenically novel SARS-CoV-2/MERS-CoV recombinants.

Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus (nih.gov)

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5 minutes ago, Manwon Lender said:

Thus, any recombination between SARS-CoV-2 and MERS-CoV genomes may generate viruses with unpredictable pathogenic potential.

Which makes that combination PRECISELY THE SAME as ANY OTHER RECOMBINANT VIRAL POSSIBILITIES.  

The farther afield the fearmongers have to travel to elicit anxiety in the face of an OBVIOUSLY weakening pandemic, the more silly they look.  

LAWDY, LAWDY... WE ALL GONE DIE!!!!!!!!!!  :huh::lol:

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1 hour ago, and then said:

Which makes that combination PRECISELY THE SAME as ANY OTHER RECOMBINANT VIRAL POSSIBILITIES.  

The farther afield the fearmongers have to travel to elicit anxiety in the face of an OBVIOUSLY weakening pandemic, the more silly they look.  

LAWDY, LAWDY... WE ALL GONE DIE!!!!!!!!!!  :huh::lol:

No we are not all going to die, most likely only the frightened unvaccinated people around the world have a very high chance of that!, Sorry if this thread has caused your anxiety to jump to new heights that was not my intention!!:w00t::D I hope the information I included for should calm your fears, hope you dont lose any sleep over this!:tu:

But, no this is not like any other possible recombinant Virus ( please name one with a 35% mortaility rate that has created a worldwide Pandemic and dont say the Spanish Flu because the mortality rate was only 5.4% ) because there are no other situations I am aware of where two deadly viruses from the same genome are circulating at the same time. 

Situation update published, 7 January 2022

MERS-CoV worldwide overview -- From 1 January 2021 to 31 December 2021, 19 MERS-CoV cases have been reported in Saudi Arabia (17) and the United Arab Emirates (2), including eight deaths. In Saudi Arabia, all were primary cases, 10 of whom reported contact with camels. These 17 cases were reported in Riyadh (10), Makkah (4), and the Eastern Province (3), for a total of all none infections is 19, with 8 fatalities. 

MERS-CoV worldwide overview (europa.eu)

Its not a question of will this occur, its a question of when it will occur worst case scenario is that a Camel that is already infected with MERS-Cov also becomes infected with SARS-Cov-2 from Human contact. Because then the recombined Viral Variant will spread rapidly through the Camel and mammal populations. The second scenario is a human infected with SARS-Cov-2 also becomes infected with MERS-Cov this scenario would be the best situation that could occur.

Because MERS-Cov has a incubation period of approximately 5 to 10 days with death occurring in many cases between the 5 to 10 day incubation period. On the other hand SARS-Cov-2 currently has a incubation period of 7 to 14 days and an infected person is capable of infecting others 7 days after infection while the individual has no symptoms during this period. If a Chimera variant occurs from recombination the incubation period could be anywhere between 0 and 14 days.

The Mortality could be anywhere between 3% to 35% and both the incubation period and the mortality rate of a variant created by recombination could be a very deadly game changer.

Long term evolution of SARS-CoV-2, 26 July 2021 - GOV.UK (www.gov.uk)

 

Edited by Manwon Lender
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1 hour ago, Manwon Lender said:

The Mortality could be anywhere between 3% to 35% and both the incubation period and the mortality rate of a variant created by recombination could be a very deadly game changer.

A comet or massive asteroid, COULD hit my house, too.  Your pandemic is ending and the ability to instill fear and control is waning faster than the "immunity" you got from your vaccine.  :lol:

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2 hours ago, and then said:

Which makes that combination PRECISELY THE SAME as ANY OTHER RECOMBINANT VIRAL POSSIBILITIES.  

The farther afield the fearmongers have to travel to elicit anxiety in the face of an OBVIOUSLY weakening pandemic, the more silly they look.  

Not exactly ....  the two viruses need to be somewhat related. Exactly how closely related, is unclear to me at present, but it's worth pondering here.

As for what "weakens," I see our institutions on the verge of collapse ....  save, the elect, which isn't a human institution per se.

I agree that Omicron looks more like a cold, and less like MERS or SARS-Cov-1, but should we imagine that the Earth is incapable of finishing off the United States, to make an example?

 

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I'm looking for the post where a poster here was saying the next variant will come along and likely be more deadly. I disagreed and said it is almost certainly gonna be milder again.

Anyway, hello Omicron BA.2 

So mild that they nearly missed that sucker.

So predictable too.

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