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Unprecedented Detail: Researchers Capture How Genes Fold and Work

Grim Reaper 6

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A new imaging technique captures the three-dimensional architecture of the human genome with unprecedented detail, showing how individual genes fold at the level of nucleosomes, the fundamental units constituting the genome’s three-dimensional architecture. The technology, which was created by Barcelona-based researchers at the Centre for Genomic Regulation (CRG) and the Institute for Research in Biomedicine (IRB Barcelona), combines high-resolution microscopy with sophisticated computer modeling. It is the most comprehensive technique to date for studying the shape of genes.

The new technique allows researchers to create and digitally navigate three-dimensional models of genes, seeing not just their architecture but also information on how they move or how flexible they are. Understanding how genes function might help us better understand how they influence the human body in both health and disease since almost every human disease has some genetic basis.


MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution: https://www.nature.com/articles/s41594-022-00839-y

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