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Science & Technology

Scientists reveal anti-aging breakthrough

December 15, 2016 | Comment icon 7 comments



Can reprogrammed cells help reverse the aging process ? Image Credit: sxc.hu
A new technique has succeeded in increasing the life span of a mouse by reprogramming some of its cells.
"What we and other stem-cell labs have observed is that when you induce cellular reprogramming, cells look younger," said Salk Institute researcher Alejandro Ocampo.

"The next question was whether we could induce this rejuvenation process in a live animal."

It's an idea that has been attempted before, however during previous experiments the mice tended to develop tumors because the treatment caused cells to start dividing uncontrollably.

To avoid this, the researchers temporarily altered four genes involved in cellular programming.
"In other studies scientists have completely reprogrammed cells all the way back to a stem-cell-like state," said study co-author Pradeep Reddy.

"But we show, for the first time, that by expressing these factors for a short duration you can maintain the cell's identity while reversing age-associated hallmarks."

The results of the study indicated a 30% increase in the life span of prematurely aged mice.

"Obviously, mice are not humans and we know it will be much more complex to rejuvenate a person," said Professor Izpisua Belmonte.

"But this study shows that ageing is a very dynamic and plastic process, and therefore will be more amenable to therapeutic interventions than what we previously thought."

Source: Independent | Comments (7)


Recent comments on this story
Comment icon #1 Posted by brlesq1 6 years ago
Hollywood types are lining up for human trials...
Comment icon #2 Posted by third_eye 6 years ago
great ... now the botoxians can live longer looking like botoxians ~
Comment icon #3 Posted by paperdyer 6 years ago
Going to put a lot of plastic surgeons out of business, I mean practice!.   I also liked the "Obviously mice aren't humans..."  Yet we experiment with and on them like they are.  Anything that affects them is automatically transferred to affecting humans as well before we actually find out if it does.
Comment icon #4 Posted by Parsec 6 years ago
Oh yeah, now we can finally work the 30% more of our lives! 
Comment icon #5 Posted by Parsec 6 years ago
Actually, rather than living the 30% more, if we could die let's say 80-90 years old, but with a body of a 50-60 years old, I'd probably go for that. 
Comment icon #6 Posted by pallidin 6 years ago
Humans are primates, while mice are not, of course. Whilst in the endeavor to find new biologic treatments for humans, it only makes sense to advance the tests first on other primates such as monkeys... Genetically similar. But, radical animal advocates have cried for years that this is cruel. Thus, the science to better our own species suffers, and we are reduced to using mice. This causes a huge chasm as to what might work in humans.  
Comment icon #7 Posted by Four Winds 6 years ago
Whatever they are doing, they need to work on it faster because try as I may I keep getting older.


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