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Colossal Biosciences wants to breed its de-extincted 'dire wolf' pups

By T.K. Randall
May 10, 2026 · Comment icon 7 comments
Dire wolves
Image: AI-generated (Midjourney)
A firm that claims to have brought the extinct dire wolf back to life is hoping to create a breeding population of the animals.
Just over a year ago, Texas-based firm Colossal Biosciences revealed that it had succeeded in bringing dire wolves back from extinction - the first time that any extinct species had ever been resurrected using modern 'de-extinction' techniques.

To achieve this, scientists used cloning and gene-editing techniques.

"This massive milestone is the first of many coming examples demonstrating that our end-to-end de-extinction technology stack works," Colossal's chief executive Ben Lamm said at the time.

"Our team took DNA from a 13,000 year old tooth and a 72,000 year old skull and made healthy dire wolf puppies."

While this achievement would seem to be impressive, the claim has since been met with some significant skepticism from the scientific community, with many arguing that the pups aren't true dire wolves.
Even so, the firm is showing no signs of slowing down and now, according to reports, it is hoping to create more pups so that it will have a viable breeding population of the animals.

"The plan is to create an inter-breedable population of dire wolves in which they would eventually breed naturally to create a sustainable population of the world's first de-extinct species," chief animal officer Matt James told The Telegraph.

"We will grow the population through assisted reproduction initially and then eventually only rely on natural breeding."

As things stand, the pups born last year are understood to be doing very well.

"The three dire wolves live on a 2,000-acre secure, expansive ecological preserve that allows us to monitor and manage them while providing them a semi-wild habitat to thrive in," said Lamm.

"We hope to have more dire wolf pups by the end of the year."



Source: Mail Online | Comments (7)




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Recent comments on this story
Comment icon #1 Posted by Almighty Evan 4 days ago
How soon until boutique DNA labs offer Cro-Magnon or Neanderthal de-extinction with modern humans?
Comment icon #2 Posted by Cho Jinn 3 days ago
Awesome.  Let's hope we don't overbreed these into near-death teacup accessory animals.
Comment icon #3 Posted by cormac mac airt 3 days ago
They need to quit trying to pass these animals off as Dire Wolves as they are no such thing, being merely genetically modified Grey Wolves.  cormac
Comment icon #4 Posted by Amorlind 3 days ago
This subject has already been explored a while ago...Dire Wolves wont come back...what they did at Colossal was to use poor genetic material at their disposal and mix it with other materials in no way related to the dire wolf genetic branch. All they do is surfing on the Game of Thrones universe to attract investors...pity...
Comment icon #5 Posted by iAlrakis 3 days ago
I wonder what they will do with all the wolves once they've achieved their goal. Also, they can observe and learn a few things but they can only guess what will happen in the long run. It's of course easier to play god with animals it raises way less flags about ethics.
Comment icon #6 Posted by Buzz_Light_Year 3 days ago
Dire Wolves aren't really wolves to begin with according to research.  https://www.scientificamerican.com/article/dire-wolves-were-not-really-wolves-new-genetic-clues-reveal/
Comment icon #7 Posted by Amorlind 2 days ago
Morevoer by creating new breeds like this, we never know what kind of disease they can bring, or how they could react to existing diseases...thus threatening an existing ecosytem already in wrong shape.


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