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Human lifespan is only 38 years, study claims


Posted on Saturday, 14 December, 2019 | Comment icon 52 comments

Are we really only supposed to live for 38 years ? Image Credit: sxc.hu
A new method for determining lifespans from DNA has offered up a perplexing figure for our 'natural' lifespan.
Writing for The Conversation, CSIRO molecular biologist and bioinformatician Benjamin Mayne explains the research that he and his colleagues conducted as part of this fascinating new study.



Humans have a "natural" lifespan of around 38 years, according to a new method we have developed for estimating the lifespans of different species by analyzing their DNA.

Extrapolating from genetic studies of species with known lifespans, we found that the extinct woolly mammoth probably lived around 60 years and bowhead whales can expect to enjoy more than two and a half centuries of life.

Our research, published today in Scientific Reports, looked at how DNA changes as an animal ages - and found that it varies from species to species and is related to how long the animal is likely to live.

The mystery of ageing

The ageing process is very important in biomedical and ecological research. As animals grow older, they experience a decline of biological functions, which limits their lifespan. Until now it has been difficult to determine how many years an animal can live.

DNA is the blueprint of living organisms and it is an obvious place to seek insights into ageing and lifespan. However, no-one has been able to find differences in DNA sequences that account for differences in lifespans.

Lifespans among vertebrates varies greatly. The pygmy goby (Eviota sigillata) is a small fish that lives only eight weeks, whereas individual Greenland sharks (Somniosus microcephalus) have been found that lived for more than 400 years.

Knowing the lifespan of wild animals is fundamental for wildlife management and conservation. For endangered species, lifespan can be used to understand what populations are viable. In industries such as fisheries, lifespan is used in population models to determine catch limits.

However, the lifespan of most animals is unknown. Most estimates come from a small number of individuals living in captivity whose ages at death were known. For long-lived species it is difficult to obtain a lifespan as they may outlive a generation of researchers.

Using changes in DNA to measure age

Over the past few years researchers have developed DNA "clocks" that can determine how old an animal is using a special type of change in the DNA called DNA methylation.
DNA methylation does not change the underlying sequence of a gene but controls whether it is active. Other researchers have shown that DNA methylation in specific genes is associated with the maximum lifespan of some mammals such as primates.

Despite DNA methylation being linked to ageing and lifespan, no research until now has used it as a method to estimate the lifespan of animals.

In our research, we have used 252 genomes (full DNA sequences) of vertebrate species that other researchers have assembled and made publicly available in an online database. We then compared these genomes to another database of known animal lifespans.

Using this data, we found that we could estimate the lifespan of vertebrate species by looking at where DNA methylation occurs in 42 particular genes. This method also lets us estimate the lifespans of long-lived and extinct species.

Extinct species

We found the lifespan of the bowhead whale, thought to be the world’s longest lived mammal, is 268 years. This estimate is 57 years higher than the oldest individual that has been found, so they may have a much longer lifespan than previously thought.

We also found the extinct woolly mammoth had a lifespan of 60 years, similar to the 65-year span of the modern-day African elephant.

The extinct Pinta Island giant tortoise had a lifespan of 120 years by our estimate. The last member of this species, Lonesome George, died in 2012 at age 112.

Interestingly, we found Neanderthals and Denisovans, which are extinct species closely related to modern humans, had a maximum lifespan of 37.8 years.

Based on DNA, we also estimated a "natural" lifespan modern humans of 38 years. This matches some anthropological estimates for early modern humans. However, humans today may be an exception to this study as advances in medicine and lifestyle have extended the average lifespan.

As more scientists assemble the genomes of other animals, our method means their lifespans can readily be estimated. This has huge ecological and conservation significance for many species which require better wildlife management.

Benjamin Mayne, Molecular biologist and bioinformatician, CSIRO.

This article is republished from The Conversation under a Creative Commons license. Read the original article.The Conversation

Source: The Conversation | Comments (52)


Tags: DNA, Lifespan


Recent comments on this story
Comment icon #43 Posted by Manwon Lender on 15 December, 2019, 7:00
I am certain that it works, I even suspect it was used by Native Americans and certainly by trappers and mountain men. But like you said today it would certainly be more time consuming, however, if push comes to shove it will still work. It's also great for an antiseptic to treat Exterior wounds, just like vinegar.  Take care.
Comment icon #44 Posted by Festina Lente on 15 December, 2019, 15:27
And childbirth killled many women back in the olden day’s when men outlived women by many years —  Old Wise Men.  This fact kept many women as spinsters and this is why “Spinsters”, single women who spun fibers, were called Old Wise Women.  And then came the so called “Witch” burnings....the churches and the secularists Of Old felt  threatened by old lady healers as according to them Only “Jesus” could heal the sick without knives or poisions.  Ask Agnus Nutter, the herbalist  Health Nut who understood healthy food and exersize were necessary for good health.    
Comment icon #45 Posted by Desertrat56 on 15 December, 2019, 18:06
When I was a kid ( in the 60's) our class was told that scientists have determined that humans have a natural lifespan of 120 years.  I plan on proving that.
Comment icon #46 Posted by aztek on 16 December, 2019, 17:57
life expectancy in some gang hoods are even lower
Comment icon #47 Posted by HorusonofRah on 17 December, 2019, 12:15
I dont have Neandertal or Denisovan DNA so can't relate.
Comment icon #48 Posted by Desertrat56 on 17 December, 2019, 15:22
So you have no European ancestry at all? Welcome to the forum by the way.
Comment icon #49 Posted by HorusonofRah on 17 December, 2019, 17:23
*fingers crossed*
Comment icon #50 Posted by Noteverythingisaconspiracy on 17 December, 2019, 17:41
I will be celebratig my 18th 29th birthday in april.   
Comment icon #51 Posted by Noteverythingisaconspiracy on 17 December, 2019, 17:48
I heard that people from @sci-nerdcountry are very bright and youthfull. 
Comment icon #52 Posted by Desertrat56 on 17 December, 2019, 17:49
You all are young!  If I counted like you do I celebrated my 34th 29th birthday, but I counted backwards for a while and I turned 37 this year.  My daughter and I are the same age, (well, she is 6 monhs younger). 


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