The 18-carat gold lavatory was swiped during an overnight break-in at Blenheim Palace, Oxfordshire.
The ridiculously extravagant (and fully functional) toilet, which is worth over $1.2 million, was created by Italian artist Maurizio Cattelan.
Incredibly the solid gold throne, which was installed opposite the room in which British prime minister Winston Churchill was born, had been available for visitors to use as an actual working toilet.
"The piece of art that has been stolen is a high-value toilet made out of gold that was on display at the palace," said Detective Inspector Jess Milne of Thames Valley Police.
"Due to the toilet being plumbed in to the building, this has caused significant damage and flooding. We believe a group of offenders used at least two vehicles during the offence."
"The artwork has not been recovered at this time but we are conducting a thorough investigation to find it and bring those responsible to justice."
Ironically, Blenheim Art Foundation founder Edward Spencer-Churchill had previously joked that the gold toilet wouldn't be the "easiest thing to nick."
"Firstly, it's plumbed in and secondly, a potential thief will have no idea who last used the toilet or what they ate," he said. "So no, I don't plan to be guarding it."